Tubulin anticorps (cleaved, EEVGVD Motif)

N° du produit ABIN2444034

Cet anticorps anti-Tubulin Polyclonal Lapin (ABIN2444034) détecte spécifiquement Tubulin dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain, Souris et Boeuf (Vache).

Aperçu rapide pour Tubulin anticorps (cleaved, EEVGVD Motif) (ABIN2444034)

Antigène: Tubulin (TUB)

Reactivité: Humain, Souris, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Tubulin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Tubulin anticorps

Épitope: cleaved, EEVGVD Motif

Fonction: Alpha-Tubulin cleaved by caspase-6 Rabbit Polyclonal Antibody

Specificité: The antibody recognizes the sequence (EEVGVD) in tubulin protein. It is specific for Caspase 6 cleaved α-Tubulin. The antibody was tested in IHC and western blots of samples with Alzheimer disease (AD) (Bovine brain sample, human samples, cells lines, mice hippocampus and whole brains). When tested in null mice with IHC and WB, no immunoreactivity was observed.

Immunogène: EEVGVD peptide

Information d'application

Indications d'application: WB 1:1000,IHC 1:1000

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: If reconstituted with deionized water in 50 μL: WB 1:1000, IHC 1:1000. Optimal dilution has to be determined by the user.

Buffer: Lyophilized serum

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Lyophilized antibodies can be kept at 4°C for up to 3 months and should be kept at -20°C for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80°C) or kept at 4°C for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy. To limit antibody loss or degradation, BSA (final concentration 1%) and sodium azide (final concentration 0.02%) can be added to the suggested first dilution. It is important to first verify if those preservatives are compatible with your assay.

Date de péremption: 24 months

Détails sur Tubulin

Antigène: Tubulin (TUB)

Autre désignation: Tubulin

Sujet:

α-Tubulin cleaved by casp 6

Tubulin is the major constituent of microtubules. Microtubules are assembled from dimers of α- and β-tubulin. α-Tubulin cleaved by caspase-6 can be found in neurons, neurofibrillary tangles, neutrophil threads, and neuritic plaques in Alzheimer disease. α-Tubulin has been found to associate with the axonal microtubule-associated protein Tau, indicating that the cleavage of the functional α-Tubulin C-terminal domain by caspase-6 could alter the state of microtubules in neurons.

UniProt: Q71U36