CD40 anticorps (Extracellular Domain) (FITC)

N° du produit ABIN2451935

L’anticorps Souris Monoclonal anti-CD40 a été validé pour FACS et IHC (fro). Il convient pour détecter CD40 dans des échantillons de Humain. Il y a 3+ publications disponibles.

Aperçu rapide pour CD40 anticorps (Extracellular Domain) (FITC) (ABIN2451935)

Antigène: CD40

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD40 est conjugé à/à la FITC

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 5C3

Détail du produit anti-CD40 anticorps (FITC)

Épitope: Extracellular Domain

Stérilité: Sterile filtered

Immunogène: Recombinant extracellular domain of CD40

Isotype: IgG1 kappa

Information d'application

Indications d'application: 1. Flowcytometry
2. Immunohistochemistry (acetone-fixed fronzen section,)

Commentaires:

Conjugate: [FITC] / [IgG] = 5.5

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS with 50 % Glycerol

Agent conservateur: Azide free

Stock: -20 °C

Références pour anticorps anti-CD40 (FITC) (ABIN2451935)

Ishida, Kumanogoh, Suzuki, Akahani, Noda, Kikutani: "Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses." dans: International immunology, Vol. 15, Issue 8, pp. 1027-34, (2003) (PubMed).

Yasui, Muraoka, Takaoka-Shichijo, Ishida, Takegahara, Uchida, Kumanogoh, Suematsu, Suzuki, Kikutani: "Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals." dans: International immunology, Vol. 14, Issue 3, pp. 319-29, (2002) (PubMed).

Inui, Kaisho, Kikutani, Stamenkovic, Seed, Clark, Kishimoto: "Identification of the intracytoplasmic region essential for signal transduction through a B cell activation molecule, CD40." dans: European journal of immunology, Vol. 20, Issue 8, pp. 1747-53, (1990) (PubMed).

Détails sur CD40

Antigène: CD40

Autre désignation: CD40

Sujet: CD40 is a 45-50- kDa glycoprotein belonging to the tumor necrosis factor (TNF) receptor superfamily. CD40 is specifically expressed on the surface of B cells and specialized antigen-presenting cells such as dendritic cells and macrophages. CD40 interacts with the CD40 ligand (CD154) which is found primarily on T cells, playing a role in both humoral and cell-mediated immune responses. Activation of CD40 on B cells by CD40 ligand causes B cell proliferation, differentiation, immunoglobulin isotype switching, germinal center formation, and stimulation of the humoral memory response. This antibody reacts with a 45-48 kDa type I integral membrane glycoprotein present on peripheral blood and tonsillar B cells, but not expressed on terminally differentiated B cells. The antibody against human CD40 was produced from hybridoma (5C3) cultured in serum-free medium and purified under mild conditions by proprietary chromatography processes.

UniProt: P25942

Pathways: Signalisation NF-kappaB, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints