CD40 anticorps (Extracellular Domain) (FITC)
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- Antigène Voir toutes CD40 Anticorps
- CD40
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Épitope
- Extracellular Domain
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CD40 est conjugé à/à la FITC
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Application
- Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Stérilité
- Sterile filtered
- Immunogène
- Recombinant extracellular domain of CD40
- Clone
- 5C3
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product CD40 Anticorps primaire
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- Indications d'application
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1. Flowcytometry
2. Immunohistochemistry (acetone-fixed fronzen section,) - Commentaires
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Conjugate: [FITC] / [IgG] = 5.5
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1.0 mg/mL
- Buffer
- PBS with 50 % Glycerol
- Agent conservateur
- Azide free
- Stock
- -20 °C
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Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses." dans: International immunology, Vol. 15, Issue 8, pp. 1027-34, (2003) (PubMed).
: "Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals." dans: International immunology, Vol. 14, Issue 3, pp. 319-29, (2002) (PubMed).
: "Identification of the intracytoplasmic region essential for signal transduction through a B cell activation molecule, CD40." dans: European journal of immunology, Vol. 20, Issue 8, pp. 1747-53, (1990) (PubMed).
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Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses." dans: International immunology, Vol. 15, Issue 8, pp. 1027-34, (2003) (PubMed).
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- Antigène
- CD40
- Autre désignation
- CD40 (CD40 Produits)
- Synonymes
- anticorps Bp50, anticorps CDW40, anticorps TNFRSF5, anticorps p50, anticorps AI326936, anticorps GP39, anticorps HIGM1, anticorps IGM, anticorps IMD3, anticorps T-BAM, anticorps TRAP, anticorps Tnfrsf5, anticorps TNFSF5, anticorps CD40 molecule, anticorps CD40 antigen, anticorps CD40, anticorps Cd40
- Sujet
- CD40 is a 45-50- kDa glycoprotein belonging to the tumor necrosis factor (TNF) receptor superfamily. CD40 is specifically expressed on the surface of B cells and specialized antigen-presenting cells such as dendritic cells and macrophages. CD40 interacts with the CD40 ligand (CD154) which is found primarily on T cells, playing a role in both humoral and cell-mediated immune responses. Activation of CD40 on B cells by CD40 ligand causes B cell proliferation, differentiation, immunoglobulin isotype switching, germinal center formation, and stimulation of the humoral memory response. This antibody reacts with a 45-48 kDa type I integral membrane glycoprotein present on peripheral blood and tonsillar B cells, but not expressed on terminally differentiated B cells. The antibody against human CD40 was produced from hybridoma (5C3) cultured in serum-free medium and purified under mild conditions by proprietary chromatography processes.
- UniProt
- P25942
- Pathways
- Signalisation NF-kappaB, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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