PRNP anticorps

N° du produit ABIN2452080

Cet anticorps anti-PRNP est un anticorps Souris Monoclonal détectant PRNP dans WB et ELISA. Adapté pour Humain. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour PRNP anticorps (ABIN2452080)

Antigène: PRNP (Prion Protein (PRNP))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PRNP est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 2C5-5

Détail du produit anti-PRNP anticorps

Réactivité croisée (Details): Does not react with mouse Prion. Not tested with other species

Purification: Purified

Stérilité: Sterile filtered

Immunogène: Recombinant human PrP lacking GPI anchor expressed and purified from rabbit kidney cell line RK13

Isotype: IgG

Information d'application

Indications d'application: 1) Western blotting: ~0. 5 g/mL
2) ELISA (most suitable)
Other applications have not been tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol

Agent conservateur: Azide free

Stock: -20 °C

Références pour anticorps anti-PRNP (ABIN2452080)

Sakudo, Nakamura, Ikuta, Onodera: "Recent developments in prion disease research: diagnostic tools and in vitro cell culture models." dans: The Journal of veterinary medical science / the Japanese Society of Veterinary Science, Vol. 69, Issue 4, pp. 329-37, (2007) (PubMed).

Détails sur PRNP

Antigène: PRNP (Prion Protein (PRNP))

Autre désignation: Prion Protein

Sujet: Prion protein PrP is a membrane glycosylphosphatidylinositol(GPI) anchored glycoprotein highly expressed in neuron and glia cells as well as immune and reproductive cells. Mutations in the octapeptide repeat regions as well as elsewhere in this gene have been associated with neurodegenerative diseases such as Creutzfeldt Jakob disease, fatal familial insomnia, Gerstmann Straussler disease, Huntington disease like 1, and kuru. The infectious isoform of PrPC, known as PrPSc, is able to convert normal PrPPC proteins into the infectious isoform, which is insoluble amyloid aggregate, by changing their. Mature PrP protein in human consists of 209 amino acids. Several forms exist, one cell surface form anchored via and two forms, therefore multiple bands are observed in SDS-PAGE (Figure). conformation topological glycolipid transmembrane

UniProt: P04156

Pathways: Transition Metal Ion Homeostasis, Activated T Cell Proliferation