Sphingomyelin Synthase 2 anticorps

N° du produit ABIN2459622

Détail du produit anti-Sphingomyelin Synthase 2 anticorps

Antigène: Sphingomyelin Synthase 2 (SGMS2)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Sphingomyelin Synthase 2 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SGMS2.

Information d'application

Indications d'application: SGMS2 antibody can be used for detection of SGMS2 by ELISA at 1:312500. SGMS2 antibody can be used for detection of SGMS2 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store SGMS2 antibody at -20 °C.

Détails sur Sphingomyelin Synthase 2

Antigène: Sphingomyelin Synthase 2 (SGMS2)

Autre désignation: SGMS2 (SGMS2 Produits)

Synonymes: anticorps SMS2, anticorps 4933405A16Rik, anticorps 5133401H06Rik, anticorps AI854299, anticorps RGD1305778, anticorps spermatin, anticorps sphingomyelin synthase 2, anticorps sgms2, anticorps SGMS2, anticorps Sgms2

Sujet: SGMS2 is a bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. SGMS2 directly and specifically recognizes the choline head group on the substrate. SGMS2 also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. SGMS2 does not function strictly as a SM synthase. SGMS2 is required for cell growth.Sphingomyelin (SM) is a major component of plasma membranes. It is preferentially concentrated in the outer leaflet and has a role in the formation of lipid rafts. SM synthases (EC 2.7.8.27), such as SGMS2, produce SM in the lumen of the Golgi and on the cell surface through the transfer of phosphocholine from phosphatidylcholine onto ceramide, yielding diacylglycerol as a side product (Huitema et al., 2004 [PubMed 14685263]).

Poids moléculaire: 42 kDa

ID gène: 166929

NCBI Accession: NP_689834

UniProt: Q8NHU3