SPAG8 anticorps

N° du produit ABIN2459942

L’anticorps anti-SPAG8 Polyclonal Lapin est utilisé pour la détection de SPAG8 dans des échantillons de Humain, Souris et Rat. Il a été validé pour ELISA et WB.

Aperçu rapide pour SPAG8 anticorps (ABIN2459942)

Antigène: SPAG8 (Sperm Associated Antigen 8 (SPAG8))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPAG8 est non-conjugé

Application: ELISA, Western Blotting (WB)

Détail du produit anti-SPAG8 anticorps

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SPAG8.

Information d'application

Indications d'application: SPAG8 antibody can be used for detection of SPAG8 by ELISA at 1:62500. SPAG8 antibody can be used for detection of SPAG8 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store SPAG8 antibody at -20 °C.

Détails sur SPAG8

Antigène: SPAG8 (Sperm Associated Antigen 8 (SPAG8))

Autre désignation: SPAG8

Sujet: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. SPAG8 is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa.The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.

Poids moléculaire: 53 kDa

ID gène: 26206

NCBI Accession: NP_758516

UniProt: Q99932