PRP19 anticorps

N° du produit ABIN2462671

Cet anticorps Lapin Polyclonal détecte spécifiquement PRP19 dans WB, IHC et ELISA. Il présente une réactivité envers Humain, Souris, Rat, Chien et Poisson zèbre (Danio rerio).

Aperçu rapide pour PRP19 anticorps (ABIN2462671)

Antigène: PRP19 (PRPF19) (Pre-mRNA Processing Factor 19 (PRPF19))

Reactivité: Humain, Souris, Rat, Chien, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRP19 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-PRP19 anticorps

Purification: Antibody is purified by protein A chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PRPF19.

Information d'application

Indications d'application: PRPF19 antibody can be used for detection of PRPF19 by ELISA at 1:1562500. PRPF19 antibody can be used for detection of PRPF19 by western blot at 2.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store PRPF19 antibody at -20 °C.

Détails sur PRP19

Antigène: PRP19 (PRPF19) (Pre-mRNA Processing Factor 19 (PRPF19))

Autre désignation: PRPF19

Sujet: PRPF19 plays a role in DNA double-strand break (DSB) repair and pre-mRNA splicing reaction. It binds double-stranded DNA in a sequence-nonspecific manner. PRPF19 acts as a structural component of the nuclear framework. It may also serve as a support for spliceosome binding and activity. It is essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. It also may have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Overexpression of PRPF19 might extend the cellular life span by increasing the resistance to stress or by improving the DNA repair capacity of the cells.In S. cerevisiae, Pso4 has pleiotropic functions in DNA recombination and in error-prone nonhomologous end-joining DNA repair.

Poids moléculaire: 55 kDa

ID gène: 27339

NCBI Accession: NP_055317

UniProt: Q9UMS4

Pathways: Ribonucleoprotein Complex Subunit Organization