CDK8 anticorps

N° du produit ABIN2463684

Détail du produit anti-CDK8 anticorps

Antigène: CDK8 (Cyclin-Dependent Kinase 8 (CDK8))

Reactivité: Humain, Souris, Rat, Poisson zèbre (Danio rerio), Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDK8 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by protein A chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CDK8.

Information d'application

Indications d'application: CDK8 antibody can be used for detection of CDK8 by ELISA at 1:12500. CDK8 antibody can be used for detection of CDK8 by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store CDK8 antibody at -20 °C.

Détails sur CDK8

Antigène: CDK8 (Cyclin-Dependent Kinase 8 (CDK8))

Autre désignation: CDK8 (CDK8 Produits)

Synonymes: anticorps K35, anticorps wu:fk95h11, anticorps cyclin dependent kinase 8, anticorps cyclin-dependent kinase 8, anticorps cyclin-dependent kinase 8 S homeolog, anticorps Cyclin-dependent kinase 8, anticorps cyclin dependent kinase 19, anticorps CDK8, anticorps Cdk8, anticorps cdk8, anticorps cdk8.S, anticorps cdk-8, anticorps CDK19

Sujet: The protein encoded by CDK8 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.

Poids moléculaire: 53 kDa

ID gène: 1024

NCBI Accession: NP_001251

UniProt: P49336

Pathways: Cycle Cellulaire, Regulation of Lipid Metabolism by PPARalpha