MST1R anticorps (Internal Region)

N° du produit ABIN2469460

Détail du produit anti-MST1R anticorps

Antigène: MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))

Épitope: Internal Region

Reactivité: Humain, Singe, Roussette (Chauve-souris), Gorilla

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MST1R est non-conjugé

Application: Immunohistochemistry (IHC)

Specificité: BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Purification: Immunoaffinity Chromatography

Immunogène: MST1R antibody was raised against a peptide located near the internal domain of MST1R (Human).

Information d'application

Indications d'application: MST1R antibody can be used in immunohistochemistry starting at 20 μg/mL, and immunofluorescence.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, 0.1 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: As with all antibodies avoid freeze/thaw cycles.

Stock: 4 °C/-80 °C

Stockage commentaire: MST1R antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.

Détails sur MST1R

Antigène: MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))

Autre désignation: MST1R (MST1R Produits)

Synonymes: anticorps CD136, anticorps CDw136, anticorps PTK8, anticorps RON, anticorps Fv-2, anticorps Fv2, anticorps Ron, anticorps STK, anticorps Cdw136, anticorps Ptk8, anticorps Stk, anticorps macrophage stimulating 1 receptor, anticorps macrophage stimulating 1 receptor (c-met-related tyrosine kinase), anticorps MST1R, anticorps Mst1r

Sujet: MST1R/Ron, a HGF Receptor/MET-type protein kinase, mediates the biological activities of macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers.

ID gène: 4486

UniProt: Q04912

Pathways: Signalisation RTK