Metabotropic Glutamate Receptor 5 anticorps (N-Term)

N° du produit ABIN2469508

Cet anticorps Lapin Polyclonal détecte spécifiquement Metabotropic Glutamate Receptor 5 dans IHC. Il présente une réactivité envers Rat, Humain, Souris, Poulet, Chien, Singe, Porc, Roussette (Chauve-souris), Boeuf (Vache), Hamster, Cheval, Lapin et Gibbon.

Aperçu rapide pour Metabotropic Glutamate Receptor 5 anticorps (N-Term) (ABIN2469508)

Antigène: Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))

Reactivité: Rat, Humain, Souris, Poulet, Chien, Singe, Porc, Roussette (Chauve-souris), Boeuf (Vache), Hamster, Cheval, Lapin, Gibbon

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Metabotropic Glutamate Receptor 5 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-Metabotropic Glutamate Receptor 5 anticorps

Épitope: N-Term

Specificité: BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Purification: Immunoaffinity Chromatography

Immunogène: GRM5 antibody was raised against a peptide located in the N-Terminal extracellular domain of GRM5 (Human).

Information d'application

Indications d'application: GRM5 antibody can be used in Western Blot starting at 1:100, and immunohistochemistry starting at 1:100.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, 0.1 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: As with all antibodies avoid freeze/thaw cycles.

Stock: 4 °C/-80 °C

Stockage commentaire: GRM5 antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.

Détails sur Metabotropic Glutamate Receptor 5

Antigène: Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))

Autre désignation: GRM5

Sujet: Group I of the Metabotropic Glutamate Receptors includes GRM1 and GRM5, receptors that have been shown to activate phospholipase C. Alternative splice variants of GRM5 have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain. GRM5 is involved in inflammatory mechanical hyperalgesia and potentially in schizophrenia

ID gène: 2915

UniProt: P41594

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity