ITGA4 anticorps (C-Term)

N° du produit ABIN2469523

Cet anticorps Lapin Polyclonal détecte spécifiquement ITGA4 dans IHC. Il présente une réactivité envers Humain, Souris, Rat, Chien, Singe, Porc, Lapin, Roussette (Chauve-souris), Hamster, Gibbon et Gorilla.

Aperçu rapide pour ITGA4 anticorps (C-Term) (ABIN2469523)

Antigène: ITGA4 (Integrin alpha 4 (ITGA4))

Reactivité: Humain, Souris, Rat, Chien, Singe, Porc, Lapin, Roussette (Chauve-souris), Hamster, Gibbon, Gorilla

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ITGA4 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-ITGA4 anticorps

Épitope: C-Term

Specificité: BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Purification: Immunoaffinity Chromatography

Immunogène: Integrin alpha 4 antibody was raised against a peptide located in the C-Terminal domain of Integrin alpha 4 (Human).

Information d'application

Indications d'application: Integrin alpha 4 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 5 μg/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, 0.1 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: As with all antibodies avoid freeze/thaw cycles.

Stock: 4 °C/-80 °C

Stockage commentaire: Integrin alpha 4 antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.

Détails sur ITGA4

Antigène: ITGA4 (Integrin alpha 4 (ITGA4))

Autre désignation: Integrin alpha 4

Sujet: ITGA4 encodes integrin alpha chain 4. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Although alpha 4 is variably cleaved to yield two unlinked chains, this cleavage is unnecessary for integrin assembly and function. Alpha 4 combines with beta 1 (ITGB1) on T-cells to form the integrin very late (activation) antigen 4 (VLA-4) that can bind to the extracellular matrix molecules fibronectin or thrombospondin, and is also a ligand for the cell surface molecule vascular cell adhesion molecule 1 (VCAM-1). In addition, alpha 4 combines with beta 7 to form the lymphocyte homing receptor known as LPAM-1 (lymphocyte Peyer Patch adhesion molecule 1). Integrins are also known to participate in cell-surface mediated signalling.

ID gène: 3676

UniProt: P13612

Pathways: Integrin Complex