TLX1 anticorps (AA 300-330)

N° du produit ABIN2470149

Détail du produit anti-TLX1 anticorps

Antigène: TLX1 (T-Cell Leukemia Homeobox 1 (TLX1))

Épitope: AA 300-330

Reactivité: Souris, Humain, Rat, Lapin, Boeuf (Vache), Chien, Singe, Roussette (Chauve-souris), Cheval, Poulet, Hamster, Gibbon, Gorilla

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TLX1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Protein G Column

Immunogène: TLX1 antibody was raised against amino acids 300 - 330 of TLX1 (Human).

Isotype: IgG

Information d'application

Indications d'application: TLX1 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, immunohistochemistry starting at 5 μg/mL, and immunofluorescence starting at 10 μg/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, 0.2 % gelatin, 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: As with all antibodies avoid freeze/thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: TLX1 antibody can be stored short term 4 °C. For long term storage aliquot and store at -20 °C.

Détails sur TLX1

Antigène: TLX1 (T-Cell Leukemia Homeobox 1 (TLX1))

Autre désignation: TLX1 (TLX1 Produits)

Synonymes: anticorps Hox-11, anticorps Hox11, anticorps HOX11, anticorps TCL3, anticorps XHox11, anticorps XHox11L2, anticorps hox11, anticorps tlx1-a, anticorps TLX-1, anticorps RGD1563655, anticorps SI:dZ46P4.1, anticorps Tlx-1, anticorps ztlx-1, anticorps T cell leukemia, homeobox 1, anticorps T-cell leukemia homeobox 1, anticorps T-cell leukemia homeobox 1 L homeolog, anticorps T-cell leukemia, homeobox 1, anticorps Tlx1, anticorps TLX1, anticorps tlx1.L, anticorps tlx1

Sujet: HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35,q24) or t(10:14)(q24,qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.

ID gène: 3195

UniProt: P31314