CBLC anticorps (AA 444 - 458)

N° du produit ABIN2470158

Cet anticorps anti-CBLC est un anticorps Lapin Polyclonal détectant CBLC dans WB, ELISA, IHC, IF et IP. Adapté pour Humain.

Aperçu rapide pour CBLC anticorps (AA 444 - 458) (ABIN2470158)

Antigène: CBLC (Cbl proto-oncogene C (CBLC))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CBLC est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Détail du produit anti-CBLC anticorps

Épitope: AA 444 - 458

Purification: Immunoaffinity Chromatography

Immunogène: CBLC antibody was raised against amino acids 444 - 458 of CBLC (Human).

Information d'application

Indications d'application: CBLC antibody can be used in Western Blot, and immunohistochemistry starting at 10 μg/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: As with all antibodies avoid freeze/thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Store CBLC antibody at 4 °C or -20 °C.

Détails sur CBLC

Antigène: CBLC (Cbl proto-oncogene C (CBLC))

Autre désignation: CBLC

Sujet: Cbl-c is also known as signal transduction protein CBL-C, SH3-binding protein CBL-C, CBL-3, and RING finger protein 57. Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl-c (a.k.a. Cbl-3) is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Cbl-c knock out mice show no obvious phenotype. Thus, the physiological role of Cbl-c is not known.

ID gène: 23624

UniProt: Q9ULV8

Pathways: EGFR Signaling Pathway