Podoplanin anticorps

N° du produit ABIN2476175

L’anticorps Souris Monoclonal anti-Podoplanin a été validé pour IHC (p) et IHC (fro). Il convient pour détecter Podoplanin dans des échantillons de Humain. Il y a 3+ publications disponibles.

Aperçu rapide pour Podoplanin anticorps (ABIN2476175)

Antigène: Podoplanin (PDPN)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Podoplanin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 4D5aE5E6

Détail du produit anti-Podoplanin anticorps

Specificité: This antibody recognizes Human Podoplanin (gp36), a 36 kDa type I cell membrane-associated glycoprotein, with a broad spectrum of distribution, being strongly expressed on the lymphatic endothelium found in lung, placenta and skeletal muscle and to a lesser extent in brain, kidney and liver. Podoplanin is absent on blood endothelium and therefore This antibody is readily able to distinguish between lymphatic vessels and blood vasculature. Although the specific function of this protein is undetermined, Podoplanin is reported to be a reliable indicator of tumour lymphangiogenesis.

Attributs du produit: Purified IgG

Purification: Purified

Immunogène: ORF Human podoplanin ectodomain expressed in E.coli

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Références pour anticorps anti-Podoplanin (ABIN2476175)

Furtado, Marinkovic, Martin, Garin, Hoch, Hubner, Chen, Genden, Skobe, Lira: "Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the thyroid." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 12, pp. 5026-31, (2007) (PubMed).

Dadras, Paul, Bertoncini, Brown, Muzikansky, Jackson, Ellwanger, Garbe, Mihm, Detmar: "Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival." dans: The American journal of pathology, Vol. 162, Issue 6, pp. 1951-60, (2003) (PubMed).

Matsui, Nagy-Bojarsky, Laakkonen, Krieger, Mechtler, Uchida, Geleff, Kang, Johnson, Kerjaschki, Kang: "Lymphatic microvessels in the rat remnant kidney model of renal fibrosis: aminopeptidase p and podoplanin are discriminatory markers for endothelial cells of blood and lymphatic vessels." dans: Journal of the American Society of Nephrology : JASN, Vol. 14, Issue 8, pp. 1981-9, (2003) (PubMed).

Détails sur Podoplanin

Antigène: Podoplanin (PDPN)

Autre désignation: PODOPLANIN

Sujet: Synonyms: AGGRUS

ID gène: 10630

UniProt: Q86YL7

Pathways: Dicarboxylic Acid Transport