CTLA4 anticorps (APC)

N° du produit ABIN2567251

Cet anticorps anti-CTLA4 Monoclonal Hamster conjugué à APC (Clone UC10-4F10-11) (ABIN2567251) détecte spécifiquement CTLA4 dans FACS. L’anticorps est réactif avec des échantillons de Souris.

Aperçu rapide pour CTLA4 anticorps (APC) (ABIN2567251)

Antigène: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Reactivité: Souris

Hôte: Hamster

Clonalité: Monoclonal

Conjugué: Cet anticorp CTLA4 est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Clone: UC10-4F10-11

Détail du produit anti-CTLA4 anticorps (APC)

Specificité: The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152.

Purification: The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: Phosphate-buffered aqueous solution, ≤0.09 % Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Stock: 4 °C

Stockage commentaire: The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.

Détails sur CTLA4

Antigène: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Autre désignation: CD152

Sujet: The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152. It is a protein with a structure similar to CD28 regarding the genomic organization, amino acid sequence, and structure. CTLA-4 is expressed on activated T cells and CD25+/CD4+ Treg lymphocytes and binds the members of the B7 family, B7-1 (CD80) and B7-2 (CD86), with higher affinity than CD28. CD28 seems to provide opposing signal to T lymphocytes, while CD152 inhibits the T lymphocytes progression to an activated state and their proliferation, CD28 is a costimulator. The mouse UC10 -4F10-11 monoclonal antibody does not cross-react with the rat leukocytes.

ID gène: 12477

UniProt: P09793

Pathways: Cancer Immune Checkpoints