APOA1 anticorps

N° du produit ABIN263693

L’anticorps anti-APOA1 Monoclonal Souris est utilisé pour la détection de APOA1 dans des échantillons de Humain. Il a été validé pour RIA et EIA.

Aperçu rapide pour APOA1 anticorps (ABIN263693)

Antigène: APOA1 (Apolipoprotein A-I (APOA1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp APOA1 est non-conjugé

Application: Radioimmunoassay (RIA), Enzyme Immunoassay (EIA)

Clone: 057-10029

Détail du produit anti-APOA1 anticorps

Specificité: Recognizes Apolipoprotein A I. This antibody does not cross react with Apo AII or Apo B in competitive RIA.Aff. Const.:5 x 10e6 L/m (determined by RIA followed by Scatchard plot analysis)

Attributs du produit: Synonyms: APOA1, ApoA-I, Apo-AI, ApoAI

Purification: Protein A chromatography

Pureté: > 90 % pure (SDS-PAGE)

Immunogène: Human high density lipoprotein

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 5.3 mg/mL (OD280nm, E0.1% = 1.4)

Buffer: 10 mM Phosphate, pH 7.4 containing 150 mM Sodium chloride and 0,09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one week or (in aliquots) at -40 °C for longer. If aliquoted for long term storage, fill volume should be equal to or greater than 50% of thenominal fill volume of the vial used. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur APOA1

Antigène: APOA1 (Apolipoprotein A-I (APOA1))

Autre désignation: Apolipoprotein A I (APO AI)

Sujet: Apolipoprotein A I promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein A I is the major protein component of high density lipoprotein (HDL) in the plasma. Synthesized in the liver and small intestine, it consists of two identical chains of 77 amino acids, an 18 amino acid signal peptide is removed co-translationally and a 6 amino acid propeptide is cleaved post-translationally. Apolipoprotein A I is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. Defects in the Apolipoprotein A I gene are associated with HDL deficiency and Tangier disease. The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I. The availability of recombinant normal apoA-I should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic vascular diseases.Synonyms: APOA1, Apo-AI, ApoA-I, ApoAI

ID gène: 335

UniProt: P02647

Pathways: Regulation of Lipid Metabolism by PPARalpha, Production of Molecular Mediator of Immune Response, Lipid Metabolism