TP53I3 anticorps

N° du produit ABIN264400

Cet anticorps Souris Monoclonal détecte spécifiquement TP53I3 dans WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour TP53I3 anticorps (ABIN264400)

Antigène: TP53I3 (Tumor Protein P53 Inducible Protein 3 (TP53I3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TP53I3 est non-conjugé

Application: Western Blotting (WB)

Clone: 10A2

Détail du produit anti-TP53I3 anticorps

Specificité: Recognizes PIG3 (p53 inducible gene 3).

Attributs du produit: Synonyms: p53-induced gene 3 protein, PIG3, Tumor protein p53-inducible protein 3, Quinoneoxidoreductase PIG3

Purification: Purified

Immunogène: Hybridoma produced by the fusion of splenocytes from mice immunized with recombinanthuman PIG-3 protein. Genename: TP53I3

Isotype: IgG1

Information d'application

Indications d'application: Western Blot (5-10 μg/mL). Positive Control: Jurkat cell lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS, 0.08 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.

Date de péremption: 12 months

Détails sur TP53I3

Antigène: TP53I3 (Tumor Protein P53 Inducible Protein 3 (TP53I3))

Autre désignation: TP53I3

Sujet: P53 Inducible Gene-3 (PIG-3) may be a long-lived reporter, which may be useful for detecting transient activation of p53. The p53 tumor suppressor is the most commonly mutated gene in human cancers. The p53 protein, which is stabilized in response to different biological checkpoints, is activated by DNA damage, hypoxia, viral infection, or oncogene activation resulting in efects such as cell cycle arrest, apoptosis, senescence, differentiation, and antiangiogenesis. Other genes also implicated in the downstream effects as a result of p53 activation are: p21WAF1, GADD45, 14-3-3, bax, Fas/APO1, KILLER/ DR5, Tsp1, IGF-BP3 and others. The p53-inducible gene 3 (PIG3), was recently identified in a screen for genes induced by p53 before the onset of apoptosis. PIG3 shares significant homology with the oxidoreductases from several species. PIG3 protein is localized to the cytoplasm and induced in primary, non-transformed, and transformed cell cultures after exposure to genotoxic agents. The induction of PIG3 by p53 occurrs with delayed kinetics as compared with other p53 downstream targets, such as p21 and MDM2. PIG3 levels are increased during p53-mediated growth arrest. Elevated levels of PIG3 are maintained in cells that resume cycling in the absence of ectopic p53 expression.Synonyms: PIG3, Quinone oxidoreductase PIG3, Tumor protein p53-inducible protein 3, p53-induced gene 3 protein

ID gène: 9540

UniProt: Q53FA7

Pathways: Signalisation p53