RIT1 anticorps

N° du produit ABIN264412

Cet anticorps Souris Monoclonal détecte spécifiquement RIT1 dans WB. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour RIT1 anticorps (ABIN264412)

Antigène: RIT1 (Ras-Like Without CAAX 1 (RIT1))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RIT1 est non-conjugé

Application: Western Blotting (WB)

Clone: 14G7

Détail du produit anti-RIT1 anticorps

Specificité: This antibody detects recombinant Rit protein expressed in 293 cells. Does not cross-react with Rin protein.

Attributs du produit: Synonyms: RIBB, RIT, ROC1, Ras-like protein expressed in many tissues, Ras-like without CAAX protein1

Purification: Purified

Immunogène: Hybridoma produced by the fusion of splenocytes from mice immunized with recombinantfull-length human Rit protein and mouse myeloma cells. Genename: RIT1

Isotype: IgG1

Information d'application

Indications d'application: Western Blot (0.5-1 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: 20 mM Sodium phosphate, 150 mM Sodium Chloride, 50 % Glycerol at pH 7.5 and 3 mM Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.

Date de péremption: 12 months

Détails sur RIT1

Antigène: RIT1 (Ras-Like Without CAAX 1 (RIT1))

Autre désignation: RIT1

Sujet: Rit and its neuron-specific homologue, Rin, define a recently discovered subfamily of Ras-related GTPases. Rit and Rin are membrane-associated in spite of the fact that they lack a CAAX box or similar C-terminal lipidation motif. Rit and Rin display 64 % amino acid sequence identity and share a unique nine amino acid effector domain (DPTIEDAYK) that is 100 % conserved between the murine and human proteins. Although the effector domain sequences of Rit and Rin are very similar to that of Ras, Rit and Rin have been shown to interact with the known Ras-binding proteins RalGDS, Rlf and AF-6, but not the Raf kinases, RIN1 or the p110 subunit of PI3 kinase. For this reason, it has been suggested that Rit and Rin may play important roles in the regulation of signaling pathways distinct from those controlled by Ras.Synonyms: RIBB, RIT, ROC1, Ras-like protein expressed in many tissues, Ras-like without CAAX protein 1

ID gène: 6016

UniProt: Q92963

Pathways: Neurotrophin Signaling Pathway