RIT2 anticorps

N° du produit ABIN264413

L’anticorps anti-RIT2 Monoclonal Souris est utilisé pour la détection de RIT2 dans des échantillons de Humain et Souris. Il a été validé pour WB et IHC (p).

Aperçu rapide pour RIT2 anticorps (ABIN264413)

Antigène: RIT2 (Ras-Like Without CAAX 2 (RIT2))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RIT2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 27G2

Détail du produit anti-RIT2 anticorps

Specificité: This antibody detects recombinant Rin protein expressed in 293 cells. Does not cross-react with Rit protein.

Attributs du produit: Synonyms: RIN, ROC2, GTP-binding protein Rit2, Ras-like protein expressed in neurons, Ras-likewithout CAAX protein 2

Purification: Purified

Immunogène: Hybridoma produced by the fusion of splenocytes from mice immunized with full-lengthrecombinant human Rin protein and mouse myeloma cells. Genename: RIT2

Isotype: IgG2b

Information d'application

Indications d'application: Western Blot (0.5-1 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: 20 mM Sodium Phosphate, 150 mM Sodium Chloride, 50 % Glycerol at pH 7.5 and 3 mM Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.

Date de péremption: 12 months

Détails sur RIT2

Antigène: RIT2 (Ras-Like Without CAAX 2 (RIT2))

Autre désignation: RIT2

Sujet: Rit and its neuron-specific homologue Rin, define a recently discovered subfamily of Ras-related GTPases. Rit and Rin are membrane-associated in spite of the fact that they lack a CAAX box or similar C-terminal lipidation motif. Rit and Rin display 64 % amino acid sequence identity and share a unique nine amino acid effector domain (DPTIEDAYK) that is 100 % conserved between the murine and human proteins. Although the effector domain sequences of Rit and Rin are very similar to that of Ras, Rit and Rin have been shown to interact with the known Ras-binding proteins RalGDS, Rlf and AF-6, but not the Raf kinases, RIN1 or the p110 subunit of PI3 kinase. For this reason, it has been suggested that Rit and Rin may play important roles in the regulation of signaling pathways distinct from those controlled by Ras.Synonyms: GTP-binding protein Rit2, RIN, ROC2, Ras-like protein expressed in neurons, Ras-like without CAAX protein 2

ID gène: 6014

UniProt: Q99578

Pathways: Neurotrophin Signaling Pathway