VAV2 anticorps
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- Antigène Voir toutes VAV2 Anticorps
- VAV2 (Vav 2 Guanine Nucleotide Exchange Factor (VAV2))
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Reactivité
- Humain
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Hôte
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Mouton
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp VAV2 est non-conjugé
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Application
- Western Blotting (WB), Immunoprecipitation (IP)
- Specificité
- This antibody reacts to Vav-2 DPH.
- Purification
- Ammonium Sulfate Precipitation
- Immunogène
- A his tagged fusion protein Vav-2 corresponding to amino acid sequence 287-578 and having a Molecular Weight of 100kD
- Isotype
- IgG
- Top Product
- Discover our top product VAV2 Anticorps primaire
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- Indications d'application
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Western Blot: 1: 5,000. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Buffer
- PBS with 0.08 % Sodium Azide as preservative
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- -20 °C
- Stockage commentaire
- Store the antibody (in aliquots) at -20 °C.
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- Antigène
- VAV2 (Vav 2 Guanine Nucleotide Exchange Factor (VAV2))
- Autre désignation
- VAV2 (VAV2 Produits)
- Synonymes
- anticorps VAV-2, anticorps 2810040F13Rik, anticorps AI847175, anticorps vav guanine nucleotide exchange factor 2, anticorps vav 2 oncogene, anticorps VAV2, anticorps Vav2
- Sujet
- Vav-2 has a molecular weight of 100 kD and shares over a 50 % homology at the amino acid and nucleic acid level with Vav. Vav-2 is a ubiquitously expressed structural homolog of the Vav protooncogene that is expressed preferentially in hematopoetiic cells. Both proteins are comprised of a Dbl- homology ((DH) domain with guanosine nucleotide exchange (GEF) activity exclusively directed towards Rho/Rac GTPases, a pleckstrin homology (PH) domain, a calponin-homology (CH) region, an acidic domain (AD) a zinc finger butterfly motif, two SH3 regions and one SH2 domain. GEF activity of RhoA family G proteins is induced by tyrosine phosphorylation in wild type vav-2, and is constitutively activated in N terminus deleted oncogene forms. Constitutive expression of a Vav-2 oncoprotein may result in morphological alterations including highly enlarged cells in which karyokinesis and cytokenesis frequently are uncoupled.Synonyms: Guanine nucleotide exchange factor VAV2, VAV-2
- ID gène
- 7410
- NCBI Accession
- NP_001127870
- UniProt
- P52735
- Pathways
- Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway
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