SH3BP2
Reactivité: Humain
ELISA
Hôte: Lapin
Polyclonal
HRP
Indications d'application
Western Blot: Detects a 85 kDa band in murine fibroblasts transfected with 3BP2. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Buffer
Phosphate buffered saline and 0.08 % sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
-20 °C
Stockage commentaire
The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
3BP2 (SH3 binding protein 2) was identified as a protein binding to the SH3 domain of the Abl proto-oncogene. Murine 3BP2 cDNA encodes a 559 amino acid protein of 85 kDa consisting of an N-terminal PH domain, a C-terminal SH2 domain and intervening proline-rich sequences. 3BP2 interacts via its Sh2 domain with Syk family protein tyrosine kinases Syk, Zap70, Grb2, Cbl, PLCg 1 and LAT in T lymphocytes and contributes to the transcriptional activation of NF-AT and AP-1. Mouse 3BP2 is 66 % homologous to the human protein at the amino acid level.Synonyms: 3BP-2, 3BP2, SH3 domain-binding protein 2, SH3BP-2