RIT2 anticorps

N° du produit ABIN265015

Cet anticorps Lapin Polyclonal détecte spécifiquement RIT2 dans WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour RIT2 anticorps (ABIN265015)

Antigène: RIT2 (Ras-Like Without CAAX 2 (RIT2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RIT2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-RIT2 anticorps

Specificité: This antibody reacts to RIT2 (Rin).

Purification: Purified

Immunogène: His-tagged recombinant human Rin protein

Isotype: IgG

Information d'application

Indications d'application: Western Blot: detects recombinant Rin protein expressed in HEK-293 cells, Shows minimalcross-reactivity with Rit protein and other Ras proteins.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Détails sur RIT2

Antigène: RIT2 (Ras-Like Without CAAX 2 (RIT2))

Autre désignation: RIT2

Sujet: Rit and its neuron-specific homologue, Rin, define a recently discovered subfamily of Ras-related GTPases. Rit and Rin are membrane-associated in spite of the fact that they lack a CAAX box or similar C-terminal lipidation motif. Rit and Rin display 64 % amino acid sequence identity and share a unique nine amino acid effector domain (DPTIEDAYK) that is 100 % conserved between the murine and human proteins. Although the effector domain sequences of Rit and Rin are very similar to that of Ras, Rit and Rin have been shown to interact with the known Ras-binding proteins RalGDS, Rlf and AF-6, but not the Raf kinases, RIN1 or the p110 subunit of PI3 kinase. For this reason, it has been suggested that Rit and Rin may play important roles in the regulation of signaling pathways distinct from those controlled by Ras.Synonyms: GTP-binding protein Rit2, RIN, ROC2, Ras-like protein expressed in neurons, Ras-like without CAAX protein 2

ID gène: 6014

NCBI Accession: NP_002921

UniProt: Q99578

Pathways: Neurotrophin Signaling Pathway