TOLLIP anticorps (C-Term)

N° du produit ABIN265153

Cet anticorps Lapin Polyclonal détecte spécifiquement TOLLIP dans WB et IHC (fro). Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour TOLLIP anticorps (C-Term) (ABIN265153)

Antigène: TOLLIP (Toll Interacting Protein (TOLLIP))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TOLLIP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-TOLLIP anticorps

Épitope: C-Term

Specificité: This antibody is specific for TOLLIP. Located in the cytoplasm and phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products (5).

Purification: Purified

Immunogène: A 16 amino acid peptide from near the carboxy terminus of human TOLLIP

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 1 μg/mL. Positive Control: Rat Brain Lysate. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate buffered saline with 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.

Détails sur TOLLIP

Antigène: TOLLIP (Toll Interacting Protein (TOLLIP))

Autre désignation: TOLLIP

Sujet: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The TLRs act through adaptor molecules to activate various kinases and transcription factors (3) so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation (4). This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.Synonyms: Toll-interacting protein

ID gène: 54472

NCBI Accession: NP_061882

UniProt: Q9H0E2