FBXW7 anticorps
Aperçu rapide pour FBXW7 anticorps (ABIN265230)
Antigène
Voir toutes FBXW7 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Specificité
- This antibody detects FBXW7, widely expressed in most tissues.
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Purification
- Purified
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Immunogène
- Synthetic peptide dervied from the human FBXW7 protein
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Indications d'application
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Western Blot (1-5 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
Restrictions
- For Research Use only
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Buffer
- Phosphate buffered saline with 0.08 % sodium azide
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Conseil sur la manipulation
- Avoid repeated freezing and thawing.
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Stock
- -20 °C
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Stockage commentaire
- Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
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- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
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Autre désignation
- FBXW7
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Sujet
- Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.Synonyms: Archipelago homolog, F-box and WD-40 domain-containing protein 7, F-box protein FBX30, F-box/WD repeat-containing protein 7, FBW7, FBX30, SEL-10, SEL10, hAgo, hCDC4
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ID gène
- 55294
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NCBI Accession
- NP_001013433
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UniProt
- Q969H0
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Pathways
- Signalisation Notch, EGFR Signaling Pathway
Antigène
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