SRPRB anticorps (AA 246-265)

N° du produit ABIN265297

Cet anticorps Mouton Polyclonal détecte spécifiquement SRPRB dans WB et IHC (fro). Il présente une réactivité envers Chien et Poulet.

Aperçu rapide pour SRPRB anticorps (AA 246-265) (ABIN265297)

Antigène: SRPRB (Signal Recognition Particle Receptor, B Subunit (SRPRB))

Reactivité: Chien, Poulet

Hôte: Mouton

Clonalité: Polyclonal

Conjugué: Cet anticorp SRPRB est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-SRPRB anticorps

Épitope: AA 246-265

Specificité: This antibody detects SRPR beta.

Purification: Purified

Immunogène: Synthetic peptide corresponding to amino acids 246-265 derived from the carboxyl terminal of the canine SRbeta subunit

Isotype: IgG

Information d'application

Indications d'application: Western blot: 1 to 5 μg/mL. Immunohistochemistry. Positive control: Canine microsomal protein.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.

Détails sur SRPRB

Antigène: SRPRB (Signal Recognition Particle Receptor, B Subunit (SRPRB))

Autre désignation: SR-beta

Sujet: The receptor for Signal Recognition Particle (SRP) is the site on the endoplasmic reticulum that ribosomes translating secreted and integral membrane proteins are initially targeted to. Once the ribosome-SRP complex arrives at the SRP receptor the protein being translated is transferred to the translocation complex (Sec61) in the ER membrane. The SRP receptor is composed of two subunits SRalpha and SRbeta. The SRalpha subunit is a translocation GTPase peripherally bound to the endoplasmic reticulum by its interaction with SRbeta. SRalpha also binds to the GTPase of SRP (SRP54) and these two proteins appear to function as each others GTPase activating proteins (GAPs). Hydrolysis of GTP by SRalpha and SRP54 is thought to be involved in transfer of the nascent protein to the Sec61 complex in the ER. SRalpha has an apparent molecular weight of 72 kDa. SRbeta is a Type I transmembrane protein that spans the membrane once and contains Ras type GTPase domain. The function of the GTPase in SRbeta is unknown. The membrane spanning domain is at the amino-terminus of SRbeta. The GTPase domain encompasses three quarters of the protein and is carboxyl- of the transmembrane region. SRalpha binds to the GTPase domain of SRbeta. Heterodimerization of SRalpha and SRbeta masks the carboxyl-terminal epitope of SRbeta.Synonyms: APMCF1, PSEC0230, SR beta, SRPRB, Signal recognition particle receptor subunit beta

ID gène: 58477

NCBI Accession: NP_067026

UniProt: Q9Y5M8

Pathways: ER-Nucleus Signaling