CCR2 anticorps (APC)
-
- Antigène Voir toutes CCR2 Anticorps
- CCR2 (Chemokine (C-C Motif) Receptor 2 (CCR2))
-
Reactivité
- Humain
-
Hôte
- Souris
-
Clonalité
- Monoclonal
-
Conjugué
- Cet anticorp CCR2 est conjugé à/à la APC
-
Application
- Western Blotting (WB), ELISA, Functional Studies (Func), Immunoprecipitation (IP)
- Purification
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
- Clone
- K036C2
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product CCR2 Anticorps primaire
-
-
- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Buffer
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Protect from prolonged exposure to light. Do not freeze.
- Stock
- 4 °C
- Stockage commentaire
- The antibody solution should be stored undiluted between 2°C and 8°C
-
- Antigène
- CCR2 (Chemokine (C-C Motif) Receptor 2 (CCR2))
- Autre désignation
- CD192 (CCR2 Produits)
- Synonymes
- anticorps CC-CKR-2, anticorps CCR-2, anticorps CCR2A, anticorps CCR2B, anticorps CD192, anticorps CKR2, anticorps CKR2A, anticorps CKR2B, anticorps CMKBR2, anticorps MCP-1-R, anticorps ACKR5, anticorps CKRX, anticorps CRAM, anticorps CRAM-A, anticorps CRAM-B, anticorps HCR, anticorps Cc-ckr-2, anticorps Ccr2a, anticorps Ccr2b, anticorps Ckr2, anticorps Ckr2a, anticorps Ckr2b, anticorps Cmkbr2, anticorps mJe-r, anticorps C-C motif chemokine receptor 2, anticorps C-C motif chemokine receptor like 2, anticorps chemokine (C-C motif) receptor 2, anticorps CCR2, anticorps CCRL2, anticorps Ccr2, anticorps LOC484790
- Sujet
- CCR2 is a chemokine receptor that binds monocyte chemoattractant proteins (MCP-1, 2, 3 and 4). Two spliced variants were initially described for CCR2 (CCR2A and CCR2B). These variants differ in their terminal carboxyl tails. Monocyte adhesion to the arterial endothelium and subsequent migration into the intima are central events in the pathogenesis of atherosclerosis. CCR2 and MCP-1 have been associated to atherosclerotic plaques. MCP-1 is induced by modified-LDL in endothelial cells and may trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Local overexpression of MCP-1 at vessel walls induces infiltration of macrophages and formation of atherosclerotic lesions. Obesity induces an inflammatory state that is implicated in many clinically important complications, including insulin resistance, diabetes, atherosclerosis, and non-alcoholic fatty liver disease. CCR2 influences the development of obesity and associated adipose tissue inflammation.
- Pathways
- cAMP Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
-