Cutaneous Lymphocyte Antigen anticorps (Alexa Fluor 647)

N° du produit ABIN2657191

L’anticorps anti-Cutaneous Lymphocyte Antigen Monoclonal Rat est utilisé pour la détection de Cutaneous Lymphocyte Antigen dans des échantillons de Humain et Souris. Il a été validé pour FACS.

Aperçu rapide pour Cutaneous Lymphocyte Antigen anticorps (Alexa Fluor 647) (ABIN2657191)

Antigène: Cutaneous Lymphocyte Antigen

Reactivité: Humain, Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Alexa Fluor 647

Application: Flow Cytometry (FACS)

Clone: HECA-452

Détail du produit

Purification: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.

Isotype: IgM kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from prolonged exposure to light. Do not freeze.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C

Détail du antigène

Antigène: Cutaneous Lymphocyte Antigen

Sujet: Cutaneous lymphocyte antigen (CLA) is a 140 kD homodimer protein recognized by a unique mAb, HECA-452. It is expressed on T cells in skin, subsets of peripheral blood memory T cells, NK cells, memory B cells and dendritic cells as well as on monocytes, granulocytes, and activated endothelial cells. CLA is a carbohydrate epitope of sialic acid and fucose-modified P-selectin glycoprotein ligand-1 (PSGL-1), a surface glycoprotein expressed on the majority of peripheral blood leukocytes. CLA is a ligand for E-selectin, P-selectin, and L-selectin. It plays a role in memory lymphocyte homing, tethering, and rolling.