CD16 anticorps (Alexa Fluor 700)

N° du produit ABIN2658033

Cet anticorps Souris Monoclonal détecte spécifiquement CD16 dans FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour CD16 anticorps (Alexa Fluor 700) (ABIN2658033)

Antigène: CD16

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD16 est conjugé à/à la Alexa Fluor 700

Application: Flow Cytometry (FACS)

Clone: 3G8

Détail du produit anti-CD16 anticorps (Alexa Fluor 700)

Réactivité croisée: Chimpanzé, Babouin, Cynomolgus, Macaque rhésus, Marmoset, Capuchin Monkey, Pigtailed Macaque, Sooty mangabey (Cercocebus atys), Squirrel Monkey (Saimiri spec.), Saguinus oedipus

Purification: The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 700 under optimal conditions.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from prolonged exposure to light. Do not freeze.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C

Détails sur CD16

Antigène: CD16

Autre désignation: CD16

Sujet: CD16 is known as low affinity IgG receptor III (FcγRIII). It is expressed as two distinct forms (CD16a and CD16b). CD16a (FcγRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. It is expressed on the surface of NK cells, activated monocytes, macrophages, and placental trophoblasts in humans. CD16b (FcγRIIIB) is a 48 kD glycosylphosphatidylinositol (GPI)-anchored protein. Its extracellular domain is over 95 % homologous to that of CD16a, and it is expressed specifically on neutrophils. CD16 binds aggregated IgG or IgG-antigen complex which functions in NK cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC).

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process