IL-34 anticorps (Biotin)

N° du produit ABIN2660791

Détail du produit anti-IL-34 anticorps (Biotin)

Antigène: IL-34 (IL34) (Interleukin 34 (IL34))

Reactivité: Souris

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp IL-34 est conjugé à/à la Biotin

Application: ELISA (Detection)

Purification: The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.

Clone: Poly5193

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur IL-34

Antigène: IL-34 (IL34) (Interleukin 34 (IL34))

Autre désignation: IL-34 (IL34 Produits)

Synonymes: anticorps C16orf77, anticorps IL-34, anticorps 2010004A03Rik, anticorps AI593503, anticorps C18H16ORF77, anticorps interleukin 34, anticorps IL34, anticorps Il34

Sujet: IL-34 is a homodimeric glycoprotein which contains 241 amino acids. IL-34 is expressed in the heart, brain, lung, liver, kidney, thymus, spleen, and other organs. It specifically binds to CD115/M-CSF receptor (CSF-1 receptor or c-Fms) and activates ERK1/2 phosphorylation. The function of IL-34 overlaps with CSF-1 to regulate myeloid lineage differentiation, proliferation, and survival. Elevated levels of IL-34 are seen in the plasma of rheumatoid arthritis patients, but can be decreased in response to therapy. IL-34 levels are also increased in the serum of cancer patients and associated with poor prognosis. Mouse IL-34 shares 71 % sequence identity with human IL-34 on the amino acid level.

Pathways: Signalisation RTK