CD130/gp130 anticorps

N° du produit ABIN2664198

Cet anticorps Rat Monoclonal détecte spécifiquement CD130/gp130 dans WB, IHC, ELISA, IF, Neut, CyTOF et ICFC. Il présente une réactivité envers Souris.

Aperçu rapide pour CD130/gp130 anticorps (ABIN2664198)

Antigène: CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp CD130/gp130 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Neutralization (Neut), Cytometry by Time of Flight (CyTOF), Intracellular Flow Cytometry (ICFC)

Clone: 4H1B35

Détail du produit anti-CD130/gp130 anticorps

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG2b kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur CD130/gp130

Antigène: CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))

Autre désignation: CD130

Sujet: CD130, also known as gp130 and IL-6ST, is a type I transmembrane glycoprotein. CD130 can form receptor complexes for a family of cytokines, which include IL-6, IL-11, IL-27, LIF, and OSM, and can transduce signals for these cytokines. The 597aa extracellular domain has one Ig-like domain and five fibronectin type-III repeats. The 277a.a. intracellular domain does not have intrinsic kinase activity. Instead, it can be phosphorylated at tyrosine residues after it forms complexes with other receptor subunits, and in turn can lead to the association with JAK tyrosine kinases and the activation of STAT transcription factors, particularly STAT3.

Pathways: Signalistation JAK/STAT, Cellular Glucan Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Cancer Immune Checkpoints