DDX58 anticorps

N° du produit ABIN2664928

L’anticorps anti-DDX58 Monoclonal Souris est utilisé pour la détection de DDX58 dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour DDX58 anticorps (ABIN2664928)

Antigène: DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DDX58 est non-conjugé

Application: Flow Cytometry (FACS)

Clone: 9F1B20

Détail du produit anti-DDX58 anticorps

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG2a kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur DDX58

Antigène: DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))

Autre désignation: DDX58

Sujet: DDX58, also named RIG-1, is a member of the DExD/H-box-containing RNA helicase family. DDX58 was first reported as a retinoic acid-inducible gene and subsequently characterized as a pattern recognition receptor (PRR). DDX58 is responsible for sensing cytosolic viral RNA and has been shown to initiate innate antiviral immune responses. DDX58 is composed of two caspase recruitment domains (CARDs), a helicase domain, and a C-terminal regulatory domain (CTD). In response to virus infections, the DDX58 CTD domain binds 5'-triphosphorylated dsRNA, which induces multimerization of DDX58 with the adaptor molecule MAVS on the mitochondria through the CARD domains. MAVS transduces the signal to activate downstream transcription factors, such as IRF-3, IRF-7, and NF-κB, leading to production of proinflammatory cytokines and type I interferons.

Pathways: Activation of Innate immune Response, Hepatitis C