JAG2 anticorps

N° du produit ABIN2665211

Détail du produit anti-JAG2 anticorps

Antigène: JAG2 (Jagged 2 (JAG2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp JAG2 est non-conjugé

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography.

Clone: MHJ2-523

Isotype: IgG1 kappa, IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur JAG2

Antigène: JAG2 (Jagged 2 (JAG2))

Autre désignation: Jagged 2 (JAG2 Produits)

Synonymes: anticorps D12Ggc2e, anticorps Serh, anticorps mJagged2-1, anticorps sm, anticorps HJ2, anticorps SER2, anticorps jag2, anticorps serB, anticorps zgc:152855, anticorps jagged 2, anticorps jagged 2b, anticorps JAG2, anticorps jag2, anticorps Jag2, anticorps jag2b

Sujet: The binding of Notch ligands with their receptors results in the proteolysis of Notch and movement of intracellular portion of Notch into the nucleus. This translocation triggers a series of signaling process. The Notch receptors and their ligands are highly conserved signaling molecules throughout development. They regulate cell fate decision for various cell developments, including myogenesis, neurogenesis, and lymphocyte development. There is growing evidence that signals transmitted through different Notch ligands can differentially affect target cells. The Jagged-2 is one of the several Notch ligands identified. It is a single pass transmembrane protein consisting of a large extracellular N-terminal which includes the DSL (Delta-Serrate-Lag-2) domain, followed by a tandem array of EGF-like repeats (ELRs) and cysteine-rich domain (CRD). Jagged 2 is expressed on lymphoma cells and some other tumor cells. Jagged-2 is reported to be essential for the regulation of spermatogenesis. Notch1/Jagged-2 signaling system plays an important role for male germ cells to differentiate, T cells and B cells to differentiate.

Pathways: Signalisation Notch, Sensory Perception of Sound