NLRC4 anticorps

N° du produit ABIN2665296

Détail du produit anti-NLRC4 anticorps

Antigène: NLRC4 (NLR Family, CARD Domain Containing 4 (NLRC4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NLRC4 est non-conjugé

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography.

Clone: 6H9B13

Isotype: IgG2a kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur NLRC4

Antigène: NLRC4 (NLR Family, CARD Domain Containing 4 (NLRC4))

Autre désignation: NLRC4 (NLRC4 Produits)

Synonymes: anticorps CARD12, anticorps CLAN, anticorps CLAN1, anticorps CLANA, anticorps CLANB, anticorps CLANC, anticorps CLAND, anticorps CLR2.1, anticorps IPAF, anticorps 9530011P19Rik, anticorps Card12, anticorps NLR family CARD domain containing 4, anticorps NLR family, CARD domain containing 4, anticorps NLRC4, anticorps Nlrc4

Sujet: NLRC4 , also known as IPAF, is a member of the NOD-like receptor (NLR) family. The NLR proteins share a conserved DNA-binding NACHT domain, a caspase recruitment domain (CARD), and a leucine-rich repeat (LRR) domain responsible for pathogen pattern recognition. NLRC4 was found to play an important role in the innate immune response against bacterial infection. During Gram-negative bacteria infections, such as Shigella, Salmonella, Legionella, or Pseudomonas, NLRC4 detects and is activated by translocated bacterial flagellin or PrgJ-like rod proteins subsequently resulting in the assembly of the NLRC4 inflammasome. The activated inflammasome drives proteolytic activation of caspase-1, leading to the processing and secretion of the proinflamatory cytokines IL-1β and IL-18.

Pathways: Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome