NLRP12 anticorps

N° du produit ABIN2665297

L’anticorps anti-NLRP12 Monoclonal Souris est utilisé pour la détection de NLRP12 dans des échantillons de Humain et Souris. Il a été validé pour BCA.

Aperçu rapide pour NLRP12 anticorps (ABIN2665297)

Antigène: NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NLRP12 est non-conjugé

Application: Biochemical Assay (BCA)

Clone: 3D11A53

Détail du produit anti-NLRP12 anticorps

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG2b kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur NLRP12

Antigène: NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))

Autre désignation: NLRP12

Sujet: NLRP12, a member of the Nod-like receptor (NLR) family of proteins, was originally suggested to act as an inflammasome forming component and a modulator of NF-κB signaling. Recent studies revealed that NLRP12 plays anti-inflammatory roles, as NLRP12-deficient mice are more susceptible to chemically induced colitis, and show a more severe infiltration of granulocytes and T cells. The colitis induced in NLRP12-/- mice is associated with increased production of proinflammatory cytokines and activation of both NF-κB and ERK signaling pathways. NLRP12 was reported to attenuate canonical NF-κB signaling by inhibiting IRAK-1 phosphorylation. NLRP12 also down-regulates non-canonical NF-κB signaling through interaction with TRAF3 and the NF-κB inducing kinase NIK.

Pathways: Positive Regulation of Endopeptidase Activity, Inflammasome