NOTCH4 anticorps

N° du produit ABIN2665309

Détail du produit anti-NOTCH4 anticorps

Antigène: NOTCH4 (Notch 4 (NOTCH4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NOTCH4 est non-conjugé

Application: Immunohistochemistry (IHC), Immunoprecipitation (IP), Flow Cytometry (FACS), Cytometry by Time of Flight (CyTOF)

Purification: The antibody was purified by affinity chromatography.

Clone: MHN4-2

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur NOTCH4

Antigène: NOTCH4 (Notch 4 (NOTCH4))

Autre désignation: Notch 4 (NOTCH4 Produits)

Synonymes: anticorps INT3, anticorps NOTCH3, anticorps Int-3, anticorps Int3, anticorps N4, anticorps Notch4, anticorps notch 4, anticorps neurogenic locus notch homolog protein 4, anticorps NOTCH4, anticorps Notch4, anticorps LOC100712850

Sujet: Neurogenic locus notch homolog protein 4 (Notch 4) is a transmembrane heterodimer in which the extracellular domain contains 29 EGF repeats and 3 LNR repeats. The intracellular domain contains 5 ANK repeats, 1 PEST motif, and 1 RAM23 domain. Notch 4 controls many developmental processes in the cell such as differentiation, proliferation, and apoptosis. In addition, it also plays a role in vascular, renal, and hepatic development. Notch 4 is expressed by a variety of tissues such as heart, lung, placenta, liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow, and fetal liver. The Notch 4 ligands are Jagged1, Jagged2, Delta1, Delta3 and Delta4. After ligand binding, Notch 4 is cleaved by the TNF-α converting enzyme (TACE). The extracellular domain remains on the cell surface while the intracellular domain is released and translocated to the nucleus where it binds to CBF-1, leading to the expression of genes of the Hairy/Enhancer of Split (HES) and HES-related repressor protein (HERP) families.

Pathways: Signalisation Notch