MLL/KMT2A anticorps (AA 2829-2883)

N° du produit ABIN2668494

Cet anticorps Lapin Polyclonal détecte spécifiquement MLL/KMT2A dans WB, ChIP, ICC, ChIP-seq et IF. Il présente une réactivité envers Humain et Souris et a été mentionné dans 5+ publications.

Aperçu rapide pour MLL/KMT2A anticorps (AA 2829-2883) (ABIN2668494)

Antigène: MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MLL/KMT2A est non-conjugé

Application: Western Blotting (WB), Chromatin Immunoprecipitation (ChIP), Immunocytochemistry (ICC), ChIP DNA-Sequencing (ChIP-seq), Immunofluorescence (IF)

Détail du produit anti-MLL/KMT2A anticorps

Épitope: AA 2829-2883

Purification: Protein A Chromatography

Immunogène: This MLL / HRX antibody was raised against a recombinant protein corresponding to amino acids 2829-2883 of human MLL.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1 μg/μL

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation:

Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Stock: -20 °C

Stockage commentaire: Antibodies in solution can be stored at -20 °C for 2 years.

Date de péremption: 6 months

Références pour anticorps anti-MLL/KMT2A (ABIN2668494)

Kühn, Löscher, Marschalek: "The IRX1/HOXA connection: insights into a novel t(4;11)- specific cancer mechanism." dans: Oncotarget, Vol. 7, Issue 23, pp. 35341-52, (2016) (PubMed).

Kang, Piao, Ryu, Kang, Chang, Keum, Hyun: "Interaction of DNA demethylase and histone methyltransferase upregulates Nrf2 in 5-fluorouracil-resistant colon cancer cells." dans: Oncotarget, Vol. 7, Issue 26, pp. 40594-40620, (2016) (PubMed).

Ahmad, Katryniok, Scholz, Merkens, Löscher, Marschalek, Steinhilber: "Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL." dans: Oncogenesis, Vol. 3, pp. e127, (2014) (PubMed).

Pradeepa, Grimes, Taylor, Sutherland, Bickmore: "Psip1/Ledgf p75 restrains Hox gene expression by recruiting both trithorax and polycomb group proteins." dans: Nucleic acids research, Vol. 42, Issue 14, pp. 9021-32, (2014) (PubMed).

Wilkinson, Ballabio, Geng, North, Tapia, Kerry, Biswas, Roeder, Allis, Melnick, de Bruijn, Milne: "RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction." dans: Cell reports, Vol. 3, Issue 1, pp. 116-27, (2013) (PubMed).

Détails sur MLL/KMT2A

Antigène: MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))

Autre désignation: MLL / HRX

Poids moléculaire: 180 kDa

ID gène: 4297

Pathways: L'effet Warburg