TET2 anticorps (AA 1-300)

N° du produit ABIN7938526

Cet anticorps Souris Monoclonal détecte spécifiquement TET2 dans WB, IP, IF et ICC. Il présente une réactivité avec des échantillons de Humain. Il a été cité dans 2+ publications.

Aperçu rapide pour TET2 anticorps (AA 1-300) (ABIN7938526)

Antigène: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TET2 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 21F11

Détail du produit anti-TET2 anticorps

Épitope: AA 1-300

Fonction: Tet2 antibody (mAb) (Clone 21F11)

Purification: Protein A Chromatography

Immunogène: This antibody was raised against a recombinant protein corresponding to amino acids 1-300 of human Tet2.

Isotype: IgG1 kappa

Information d'application

Indications d'application: IP: 1 - 2 µL per IP WB: 1 - 2 μg/mL dilution

Restrictions: For Research Use only

Stockage

Concentration: 1 μg/μL

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Stock: -20 °C

Stockage commentaire: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Date de péremption: 24 months

Références pour anticorps anti-TET2 (ABIN7938526)

Wallner, Schröder, Leitão, Berulava, Haak, Beißer, Rahmann, Richter, Manke, Bönisch, Arrigoni, Fröhler, Klironomos, Chen, Rajewsky, Müller, Ebert, Lengauer, Barann, Rosenstiel, Gasparoni, Nordström et al.: "Epigenetic dynamics of monocyte-to-macrophage differentiation. ..." dans: Epigenetics & chromatin, Vol. 9, pp. 33, (2016) (PubMed).

Gong, Guo, Niu, Jin, Zhang, Shi, Zhang, Li, Chen, Ma: "Epigenetic silencing of TET2 and TET3 induces an EMT-like process in melanoma." dans: Oncotarget, Vol. 8, Issue 1, pp. 315-328, (2016) (PubMed).

Détails sur TET2

Antigène: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Autre désignation: Tet2

Sujet: Tet2 (tet methylcytosine dioxygenase 2) catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Plays an important role in myelopoiesis. The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation and differentiation in the case of inflammation by regulating gene expression and macrophage differentiation.

Poids moléculaire: 220 kDa

ID gène: 54790

NCBI Accession: NP_001120680

Pathways: L'effet Warburg