Retinoic Acid Receptor alpha anticorps (AA 420-443)

N° du produit ABIN2668711

Il existe 2+ publications pour ce produit. L’anticorps anti-Retinoic Acid Receptor alpha Monoclonal Souris est utilisé pour la détection de Retinoic Acid Receptor alpha dans des échantillons de Humain et Souris. Il a été validé pour WB, IHC et SSA.

Aperçu rapide pour Retinoic Acid Receptor alpha anticorps (AA 420-443) (ABIN2668711)

Antigène: Retinoic Acid Receptor alpha (RARA) (Retinoic Acid Receptor, alpha (RARA))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Retinoic Acid Receptor alpha est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Supershift Assay (SSA)

Clone: 9alpha-9A6

Détail du produit anti-Retinoic Acid Receptor alpha anticorps

Épitope: AA 420-443

Fonction: RAR-alpha antibody (mAb) (Clone 9a-9A6)

Purification: Protein A Chromatography

Immunogène: This RAR-a antibody was raised against a recombinant protein corresponding to amino acids 420-443 (the F region) of human RARa.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.71 μg/μL

Buffer: Purified IgG in 60 mM Sodium Citrate, 105 mM Tris-HCl, 30 % glycerol, and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Stock: -20 °C

Stockage commentaire: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Date de péremption: 24 months

Références pour anticorps anti-Retinoic Acid Receptor alpha (ABIN2668711)

Quere, Baudet, Cassinat, Bertrand, Marti, Manchon, Piquemal, Chomienne, Commes: "Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity." dans: Blood, Vol. 109, Issue 10, pp. 4450-60, (2007) (PubMed).

Reichrath, Mittmann, Kamradt, Müller: "Expression of retinoid-X receptors (-alpha,-beta,-gamma) and retinoic acid receptors (-alpha,-beta,-gamma) in normal human skin: an immunohistological evaluation." dans: The Histochemical journal, Vol. 29, Issue 2, pp. 127-33, (1997) (PubMed).

Détails sur Retinoic Acid Receptor alpha

Antigène: Retinoic Acid Receptor alpha (RARA) (Retinoic Acid Receptor, alpha (RARA))

Autre désignation: RAR-alpha

Sujet: Retinoic acid receptors (RAR) are nuclear receptors that are activated by both all-trans retinoic acid and 9-cis retinoic acid. There are three retinoic acid receptors (RAR), RAR-a, RAR-b and RAR-g. RAR-a (Nuclear receptor subfamily 1 group B member 1, NR1B1) interacts with NCoA3, NCoA6, NCoA7 and MLL to activate transcription of target genes. Chromosomal aberrations of RAR-a are sometimes involved in Promyelocytic leukemia.

Poids moléculaire: 52 kDa

ID gène: 5914

NCBI Accession: NP_001138773

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, S100 Proteins