RBPJ anticorps

N° du produit ABIN2668739

Cité dans 1 publication. Cet anticorps anti-RBPJ Monoclonal Rat (Clone 7A11) (ABIN2668739) détecte spécifiquement RBPJ dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour RBPJ anticorps (ABIN2668739)

Antigène: RBPJ (Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ))

Reactivité: Humain

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp RBPJ est non-conjugé

Application: Western Blotting (WB)

Clone: 7A11

Détail du produit anti-RBPJ anticorps

Fonction: RBPJ antibody (mAb) (Clone 7A11)

Purification: Protein G Chromatography

Immunogène: This antibody was raised against full-length recombinant human RBPJ protein.

Isotype: IgG2b

Information d'application

Indications d'application: WB: 2 - 4 μg/mL dilution

Restrictions: For Research Use only

Stockage

Concentration: 1 μg/μL

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Stock: -20 °C

Stockage commentaire: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Date de péremption: 24 months

Références pour anticorps anti-RBPJ (ABIN2668739)

Maier, Santak, Mantik, Grabusic, Kremmer, Hammerschmidt, Kempkes et al.: "A somatic knockout of CBF1 in a human B-cell line reveals that induction of CD21 and CCR7 by EBNA-2 is strictly CBF1 dependent and that downregulation of immunoglobulin M is partially CBF1 ..." dans: Journal of virology, Vol. 79, Issue 14, pp. 8784-92, (2005) (PubMed).

Détails sur RBPJ

Antigène: RBPJ (Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ))

Autre désignation: RBPJ

Sujet: RBPJ (Recombination Signal Binding Protein For Immunoglobulin Kappa J Region) is a transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA.

Poids moléculaire: 55 kDa

ID gène: 3516

NCBI Accession: NP_005340

Pathways: Signalisation Notch, Stem Cell Maintenance, Smooth Muscle Cell Migration