5-Hydroxymethylcytosine anticorps

N° du produit ABIN2668980

Cet anticorps Lapin Polyclonal détecte spécifiquement 5-Hydroxymethylcytosine dans DB et MeDIP. Il présente une réactivité envers et a été mentionné dans 15+ publications.

Aperçu rapide pour 5-Hydroxymethylcytosine anticorps (ABIN2668980)

Antigène: 5-Hydroxymethylcytosine (5-hmC)

Reactivité: Veuillez nous consulter SVP

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp 5-Hydroxymethylcytosine est non-conjugé

Application: Dot Blot (DB), Methylated DNA Immunoprecipitation (MeDIP)

Détail du produit anti-5-Hydroxymethylcytosine anticorps

Purification: Protein A Chromatography

Immunogène: This 5-Hydroxymethylcytidine antibody was raised against 5-hydroxymethylcytidine conjugated to KLH and recognizes 5-hydroxymethylcytosine.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1 μg/μL

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation:

Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Stock: -20 °C

Stockage commentaire: Antibodies in solution can be stored at -20 °C for 2 years.

Date de péremption: 6 months

Références pour anticorps anti-5-Hydroxymethylcytosine (ABIN2668980)

Wiehle, Raddatz, Musch, Dawlaty, Jaenisch, Lyko, Breiling: "Tet1 and Tet2 Protect DNA Methylation Canyons against Hypermethylation." dans: Molecular and cellular biology, Vol. 36, Issue 3, pp. 452-61, (2016) (PubMed).

Barazeghi, Gill, Sidhu, Norlén, Dina, Palazzo, Hellman, Stålberg, Westin: "5-Hydroxymethylcytosine discriminates between parathyroid adenoma and carcinoma." dans: Clinical epigenetics, Vol. 8, pp. 31, (2016) (PubMed).

Uribe-Lewis, Stark, Carroll, Dunning, Bachman, Ito, Stojic, Halim, Vowler, Lynch, Delatte, de Bony, Colin, Defrance, Krueger, Silva, Ten Hoopen, Ibrahim, Fuks, Murrell: "5-hydroxymethylcytosine marks promoters in colon that resist DNA hypermethylation in cancer." dans: Genome biology, Vol. 16, pp. 69, (2015) (PubMed).

Chen, Aksoy, Gonnot, Osteil, Aubry, Hamela, Rognard, Hochard, Voisin, Fontaine, Mure, Afanassieff, Cleroux, Guibert, Chen, Vallot, Acloque, Genthon, Donnadieu, De Vos, Sanlaville, Guérin, Weber et al.: "Reinforcement of STAT3 activity reprogrammes human embryonic stem cells to naive-like pluripotency. ..." dans: Nature communications, Vol. 6, pp. 7095, (2015) (PubMed).

Eleftheriou, Pascual, Wheldon, Perry, Abakir, Arora, Johnson, Auer, Ellis, Madhusudan, Ruzov: "5-Carboxylcytosine levels are elevated in human breast cancers and gliomas." dans: Clinical epigenetics, Vol. 7, pp. 88, (2015) (PubMed).

Zhao, Yang, Wang, Chong, Yin, Song, Zhao, Li, Huang, Sun, Wu, Jin, Song, Zhu, Jiang, Rendtlew Danielsen, Xu, Yang, Wang: "Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism." dans: Nucleic acids research, Vol. 42, Issue 3, pp. 1593-605, (2014) (PubMed).

Müller, Bauer, Siegl, Rottach, Leonhardt: "TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation." dans: Nucleic acids research, Vol. 42, Issue 13, pp. 8592-604, (2014) (PubMed).

Hashimoto, Pais, Zhang, Saleh, Fu, Dai, Corrêa, Zheng, Cheng: "Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA." dans: Nature, Vol. 506, Issue 7488, pp. 391-5, (2014) (PubMed).

Colquitt, Allen, Barnea, Lomvardas: "Alteration of genic 5-hydroxymethylcytosine patterning in olfactory neurons correlates with changes in gene expression and cell identity." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 36, pp. 14682-7, (2013) (PubMed).

Yamaguchi, Hong, Liu, Inoue, Shen, Zhang, Zhang: "Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming." dans: Cell research, Vol. 23, Issue 3, pp. 329-39, (2013) (PubMed).

Shen, Wu, Diep, Yamaguchi, DAlessio, Fung, Zhang, Zhang: "Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics." dans: Cell, Vol. 153, Issue 3, pp. 692-706, (2013) (PubMed).

Leitch, McEwen, Turp, Encheva, Carroll, Grabole, Mansfield, Nashun, Knezovich, Smith, Surani, Hajkova: "Naive pluripotency is associated with global DNA hypomethylation." dans: Nature structural & molecular biology, Vol. 20, Issue 3, pp. 311-6, (2013) (PubMed).

Bocker, Tuorto, Raddatz, Musch, Yang, Xu, Lyko, Breiling: "Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster." dans: Nature communications, Vol. 3, pp. 818, (2012) (PubMed).

Wu, DAlessio, Ito, Wang, Cui, Zhao, Sun, Zhang: "Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells." dans: Genes & development, Vol. 25, Issue 7, pp. 679-84, (2011) (PubMed).

Li, Cai, Cai, Wang, Zhang, Petersen, Yang, Xu: "Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies." dans: Blood, Vol. 118, Issue 17, pp. 4509-18, (2011) (PubMed).

Détails sur 5-Hydroxymethylcytosine

Antigène: 5-Hydroxymethylcytosine (5-hmC)

Autre désignation: 5-Hydroxymethylcytosine

Classe de substances: Chemical