Reacts with CD104, integrin β4 chain, a 205 kDa transmembrane glycoprotein, associated with CD49f (integrin α6 chain) to form the α6/β4 (CD49f/CD104) complex. CD104 is expressed on epithelial cells, Schwann cells, and some tumor cells. The CD49f/CD104 complex is located in the hemidesmosomes of the epidermis, suggesting its role in epidermal cell-basement membrane adhesion. The clone 450-11A recognizes the cytoplasmic domain of human CD104. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of intracellular A431 cells, an epidermal carcinoma cell line, analyzed by flow cytometry
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Jones, Kurpakus, Cooper, Quaranta: "A function for the integrin alpha 6 beta 4 in the hemidesmosome." dans: Cell regulation, Vol. 2, Issue 6, pp. 427-38, (1991) (PubMed).
Sonnenberg, Calafat, Janssen, Daams, van der Raaij-Helmer, Falcioni, Kennel, Aplin, Baker, Loizidou: "Integrin alpha 6/beta 4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell-basement membrane adhesion." dans: The Journal of cell biology, Vol. 113, Issue 4, pp. 907-17, (1991) (PubMed).
Kennel, Epler, Lankford, Foote, Dickas, Canamucio, Cavalierie, Cosimelli, Venturo, Falcioni: "Second generation monoclonal antibodies to the human integrin alpha 6 beta 4." dans: Hybridoma, Vol. 9, Issue 3, pp. 243-55, (1990) (PubMed).
Tamura, Rozzo, Starr, Chambers, Reichardt, Cooper, Quaranta: "Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4." dans: The Journal of cell biology, Vol. 111, Issue 4, pp. 1593-604, (1990) (PubMed).
Hemler, Crouse, Sonnenberg: "Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines." dans: The Journal of biological chemistry, Vol. 264, Issue 11, pp. 6529-35, (1989) (PubMed).