Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

IL2RG anticorps (Biotin)

IL2RG Reactivité: Souris FACS, Neut, BR Hôte: Rat Monoclonal TUGm2 Biotin
N° du produit ABIN2688956
  • Antigène Voir toutes IL2RG Anticorps
    IL2RG (Interleukin 2 Receptor, gamma (IL2RG))
    Reactivité
    • 72
    • 27
    • 25
    • 4
    • 1
    Souris
    Hôte
    • 60
    • 12
    • 9
    Rat
    Clonalité
    • 63
    • 18
    Monoclonal
    Conjugué
    • 35
    • 10
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp IL2RG est conjugé à/à la Biotin
    Application
    • 54
    • 33
    • 28
    • 8
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Neutralization (Neut), Blocking Reagent (BR)
    Marque
    BD Pharmingen™
    Attributs du produit
    The TUGm2 antibody reacts with Mouse CD132 which is also known as the common γ subunit (γc). The γc chain subunit is shared by the IL-2, IL-4, IL-7, IL-9, and IL-15 receptor complexes. The γc receptor is expressed constitutively at low levels by most lymphocytes, myeloid cells, embryonic thymocytes, and lymphoid cell lines. The γc receptor is a 75-80 kD transmembrane glycoprotein which mediates signal transducing activities of cytokine receptor complexes with which it is associated. TUGm2 antibody can significantly block the binding of and proliferative response to IL-4 by CTLL-2 cells. It can also inhibit binding to high-affinity IL-2 receptors expressed by CTLL-2 cells. By itself, the TUGm2 antibody reportedly fails to significantly inhibit CTLL-2 proliferative responses to IL-2. However, when added along with TM-β1 (Cat. No. 553359), specific for the mouse IL-2Rβ chain, TUGm2 was shown to synergistically reduce IL-2-driven CTLL-2 proliferative responses. TUGm2 can reduce the IL-7-induced proliferation of Con A-activated mouse splenocytes and the IL-7 responsive pre-B cell line, IxN/2b. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature.

    BD Pharmingen™ Biotin Rat Anti-Mouse CD132 - Biotin - Clone TUGm2 - Isotype Rat IgG2b, κ - Reactivity Ms - 0.5 mg
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Clone
    TUGm2
    Isotype
    IgG2b kappa
    Top Product
    Discover our top product IL2RG Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
    Stock
    4 °C
    Stockage commentaire
    Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
  • Kondo, Takeshita, Higuchi, Nakamura, Sudo, Nishikawa, Sugamura: "Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes." dans: Science (New York, N.Y.), Vol. 263, Issue 5152, pp. 1453-4, (1994) (PubMed).

    Kondo, Takeshita, Ishii, Nakamura, Watanabe, Arai, Sugamura: "Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4." dans: Science (New York, N.Y.), Vol. 262, Issue 5141, pp. 1874-7, (1994) (PubMed).

    Guesdon, Ternynck, Avrameas: "The use of avidin-biotin interaction in immunoenzymatic techniques." dans: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 27, Issue 8, pp. 1131-9, (1979) (PubMed).

  • Antigène
    IL2RG (Interleukin 2 Receptor, gamma (IL2RG))
    Autre désignation
    CD132 (IL2RG Produits)
    Synonymes
    anticorps Ab2-183, anticorps Cd132, anticorps CD132, anticorps CIDX, anticorps IL-2RG, anticorps IMD4, anticorps P64, anticorps SCIDX, anticorps SCIDX1, anticorps [g]c, anticorps gamma(c), anticorps gc, anticorps interleukin 2 receptor subunit gamma, anticorps interleukin 2 receptor subunit gamma L homeolog, anticorps interleukin 2 receptor, gamma chain, anticorps IL2RG, anticorps il2rg.L, anticorps Il2rg
    Sujet
    Synonyms: Cytokine Common γ chain, γc
    Pathways
    Signalistation JAK/STAT, Growth Factor Binding
Vous êtes ici:
Support technique