CXCR4 anticorps (Biotin)

N° du produit ABIN2689044

Il existe 5+ publications pour ce produit. L’anticorps anti-CXCR4 Monoclonal Souris est utilisé pour la détection de CXCR4 dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour CXCR4 anticorps (Biotin) (ABIN2689044)

Antigène: CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CXCR4 est conjugé à/à la Biotin

Application: Flow Cytometry (FACS)

Clone: 12G5

Détail du produit anti-CXCR4 anticorps (Biotin)

Attributs du produit: The 12G5 monoclonal antibody specifically binds to CD184, also known as CXCR4 and Fusin. CD184/CXCR4 is a seven-transmembrane domain, G-protein-linked, glycoprotein chemokine receptor. CD184 serves as a receptor for the C-X-C chemokine, SDF-1. It is expressed on a wide variety of hematopietic cells, vascular endothelial cells and cells of the nervous system. CD184 plays a variety of roles in hematopoiesis, vascularization and neural development. CD184 also functions as a coreceptor for infection with T-cell tropic strains of HIV-1 and as a receptor for CD4-independent infection by some HIV isolates. The 12G5 antibody has been reported to block CD4-independent infection by HIV-2 and CD4-dependent infection by some T-cell tropic isolates of HIV-1. Profile of peripheral blood lymphocytes analyzed by flow cytometry.

BD Pharmingen™ Biotin Mouse Anti-Human CD184 - Biotin - Clone 12G5 - Isotype Mouse IgG2a, κ - Reactivity Hu - 100 Tests

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotype: IgG2a kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Volume d'échantillon: 20 μL

Restrictions: For Research Use only

Stockage

Buffer: Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-CXCR4 (Biotin) (ABIN2689044)

Endres, Clapham, Marsh, Ahuja, Turner, McKnight, Thomas, Stoebenau-Haggarty, Choe, Vance, Wells, Power, Sutterwala, Doms, Landau, Hoxie: "CD4-independent infection by HIV-2 is mediated by fusin/CXCR4." dans: Cell, Vol. 87, Issue 4, pp. 745-56, (1997) (PubMed).

Simmons, Wilkinson, Reeves, Dittmar, Beddows, Weber, Carnegie, Desselberger, Gray, Weiss, Clapham: "Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entry." dans: Journal of virology, Vol. 70, Issue 12, pp. 8355-60, (1997) (PubMed).

Feng, Broder, Kennedy, Berger: "HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor." dans: Science (New York, N.Y.), Vol. 272, Issue 5263, pp. 872-7, (1996) (PubMed).

Loetscher, Geiser, OReilly, Zwahlen, Baggiolini, Moser: "Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes." dans: The Journal of biological chemistry, Vol. 269, Issue 1, pp. 232-7, (1994) (PubMed).

Guesdon, Ternynck, Avrameas: "The use of avidin-biotin interaction in immunoenzymatic techniques." dans: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 27, Issue 8, pp. 1131-9, (1979) (PubMed).

Détails sur CXCR4

Antigène: CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))

Autre désignation: CD184

Sujet: Synonyms: CXCR4, Fusin, SDF-1 receptor, LAP3, LCR1, LESTR, NPYY3R, NPY3R, WHIM, HM89

Pathways: Regulation of Cell Size, CXCR4-mediated Signaling Events