GP5 anticorps

N° du produit ABIN2689254

Détail du produit anti-GP5 anticorps

Antigène: GP5 (Glycoprotein V (Platelet) (GP5))

Reactivité: Souris, Rat

Hôte: Hamster arménien

Clonalité: Monoclonal

Conjugué: Cet anticorp GP5 est non-conjugé

Application: Immunoprecipitation (IP), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Marque: BD Pharmingen™

Attributs du produit: The 1C2 antibody reacts with CD42d (Platelet Glycoprotein V, GPV), a glycoprotein of 74 kDa in the mouse and 88 kDa in the rat. GPV noncovalently associates with GPIb (CD42b and c) and GPIX (CD42a) to form a receptor for von Willebrand factor on megakaryocytes and resting platelets. The binding sites for von Willebrand factor and thrombin have been localized to the GPIbachain (CD42b) of the GPIb-V-IX complex. GPV is cleaved by thrombin to release a 69- kDa soluble fragment, which contains the epitope recognized by mAb 1C2. The 1C2 antibody does not cross-react with human platelets nor with other hematopoietic cells of the mouse and rat. Anti-mouse CD41 mAb MWReg30 (Cat. No. 553848, for the FITC conjugate) may be used with mAb 1C2 to monitor mouse megakaryocyte maturation.

BD Pharmingen™ Purified Hamster Anti-Mouse and Rat CD42d - Purified - Clone 1C2 - Isotype Armenian Hamster IgG3, λ1 - Reactivity Ms, Rat - 0.5 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: (C57BL/6 x DBA/2)F1 mouse platelets

Clone: 1C2

Isotype: IgG3 lambda

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-GP5 (ABIN2689254)

Sato, Kiyokawa, Takada, Itagaki, Saito, Sekino, Suzuki, Taguchi, Mimori, Lanza, Fujimoto: "Characterization of monoclonal antibodies against mouse and rat platelet glycoprotein V (CD42d)." dans: Hybridoma, Vol. 19, Issue 6, pp. 455-61, (2001) (PubMed).

Sato, Kiyokawa, Taguchi, Suzuki, Sekino, Ohmi, Itagaki, Sato, Lepage, Lanza, Fujimoto: "Functional conservation of platelet glycoprotein V promoter between mouse and human megakaryocytes." dans: Experimental hematology, Vol. 28, Issue 7, pp. 802-14, (2000) (PubMed).

Ravanat, Morales, Azorsa, Moog, Schuhler, Grunert, Loew, Van Dorsselaer, Cazenave, Lanza: "Gene cloning of rat and mouse platelet glycoprotein V: identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage." dans: Blood, Vol. 89, Issue 9, pp. 3253-62, (1997) (PubMed).

Takada, Saito, Kaneko, Iizuka, Kokai, Fujimoto: "Novel monoclonal antibody reactive with thrombin-sensitive 74-kDa glycoproteins present on platelets and megakaryocytes both from mouse and rat." dans: Hybridoma, Vol. 14, Issue 4, pp. 361-7, (1996) (PubMed).

Détails sur GP5

Antigène: GP5 (Glycoprotein V (Platelet) (GP5))

Autre désignation: CD42d (GP5 Produits)

Synonymes: anticorps lib, anticorps GPV, anticorps PLGPV, anticorps CD42d, anticorps glycoprotein V platelet L homeolog, anticorps glycoprotein V platelet, anticorps glycoprotein 5 (platelet), anticorps glycoprotein V (platelet), anticorps gp5.L, anticorps GP5, anticorps Gp5

Sujet: Synonyms: Platelet Glycoprotein V