Transferrin Receptor anticorps

N° du produit ABIN2689385

Cet anticorps Rat Monoclonal détecte spécifiquement Transferrin Receptor dans FACS, IF, IHC (fro) et IHC (p). Il présente une réactivité envers Souris et a été mentionné dans 3+ publications.

Aperçu rapide pour Transferrin Receptor anticorps (ABIN2689385)

Antigène: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp Transferrin Receptor est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: C2

Détail du produit anti-Transferrin Receptor anticorps

Marque: BD Pharmingen™

Attributs du produit: The C2 antibody reacts with the transferrin receptor CD71, a disulfide-linked homodimer of 95- kDa subunits. CD71 mediates one of the cellular mechanisms for iron uptake, and its expression is regulated according to the cell's iron requirements. It is expressed at high levels on developing erythroid cells, and it is upregulated after mitogenic activation of B or T lymphocytes. C2 mAb selectivity inhibits some types of T- and B-cell activation by down-regulation of transferrin receptor expression, but it does not block binding of transferrin. Although the isotype of C2 mAb was originally reported to be Rat IgG2a, further investigations have demonstrated that it is Rat IgG1, κ.

BD Pharmingen™ Purified Rat Anti-Mouse CD71 - Purified - Clone C2 (also known as C2F2) - Isotype Rat IgG1, κ - Reactivity Ms - 0.5 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Mouse cell line

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-Transferrin Receptor (ABIN2689385)

Lok, Loh: "Regulation of transferrin function and expression: review and update." dans: Biological signals and receptors, Vol. 7, Issue 3, pp. 157-78, (1998) (PubMed).

Fujimoto: "GPI-anchored proteins, glycosphingolipids, and sphingomyelin are sequestered to caveolae only after crosslinking." dans: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 44, Issue 8, pp. 929-41, (1996) (PubMed).

Kemp, Thorson, Gomez, Smith, Cowdery, Ballas: "Inhibition of lymphocyte activation with anti-transferrin receptor Mabs: a comparison of three reagents and further studies of their range of effects and mechanism of action." dans: Cellular immunology, Vol. 122, Issue 1, pp. 218-30, (1989) (PubMed).

Détails sur Transferrin Receptor

Antigène: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Autre désignation: CD71

Sujet: Synonyms: Transferrin Receptor

Pathways: Transition Metal Ion Homeostasis