SMC1A anticorps (Structural Maintenance of Chromosomes 1A) (pSer360) (PE)

Details for Product anti-SMC1A Antibody No. ABIN2690293
Antigène
  • CDLS2
  • DXS423E
  • SB1.8
  • SMC1
  • SMC1L1
  • SMC1alpha
  • SMCB
  • SMC-1A
  • NV15570
  • 5830426I24Rik
  • Sb1.8
  • Smc1
  • Smc1alpha
  • Smc1l1
  • Smcb
  • mKIAA0178
  • smc1
  • smc1a
  • smc1l1
  • xSMC1
  • smc1aa
  • structural maintenance of chromosomes 1A
  • structural maintenance of chromosomes 1A b
  • structural maintenance of chromosomes 1A L homeolog
  • SMC1A
  • smc1a
  • Smc1a
  • smc1ab
  • smc1a.L
Épitope
pSer360
57
22
17
16
15
10
7
5
4
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
236
111
67
8
8
7
6
6
4
4
3
2
2
1
1
1
Hôte
Lapin
187
45
3
2
1
Clonalité
Polyclonal
Conjugué
Cet anticorp SMC1A est conjugé à/à la PE
9
7
7
7
7
7
7
4
4
2
2
2
2
2
2
2
2
Application
Flow Cytometry (FACS)
178
88
72
39
33
27
25
10
8
4
3
2
1
1
1
1
Options
Immunogène KLH conjugated synthetic phosphopeptide derived from human SMC1 around the phosphorylation site of Ser360
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others SMC1A products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation SMC1 (SMC1A Antibody Extrait)
Sujet

Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. The chromosome proteins are conserved in eukaryotes and can lead to mitotic chromosome segregation defects, suggesting a critical function of SMC family proteins in mitotic chromosome dynamics. SMC1 and SMC3 form a heterodimeric complex required for metaphase progression in mitotic cells. Specifically this SMC1/SMC3 complex is responsible for sister chromatid cohesion during metaphase. A number of cellular factors interact with hSMC1/hSMC3 during cell cycle. The major population of hSMC1/hSMC3 is in a compex with hRAD21 forming the human cohesion complex. Human cohesion complex associates with chromosomes which peaks at S phase and dissociates from chromosomes during G2/M transition. In addition, a subpopulation of hSMC1/hSMC3 associates tightly with nuclear matrix and centrosomes during interphase. A subset of hSMC1/hSMC3 is localized to spindle poles, spindles and kinetochores during mitosis when cohesin is in the cytoplasm. hSMC1/hSMC3 is required for spindle aster formation in vitro and reacts with nuclear mitotic apparatus protein in vivo.

Synonyms: CDLS2, SMC1, Segregation of mitotic chromosomes 1, Segregation of mitotic chromosomes like 1, SMC 1, SMC1A, SMC1alpha, SMC1alpha protein, SMC1B, SMC1BETA, SMC1beta protein, SMC1L1, SMC1L2, SMCB, Structural maintenance of chromosome 1 like 1 protein, Structural maintenance of chromosome 1 like 2 protein, structural maintenance of chromosomes 1-like 2 yeast, Structural maintenance of chromosomes 1A, Structural maintenance of chromosomes 1B, Structural Maintenance of Chromosomes-1 Like 1, SMC1A_HUMAN.

ID gène 8243
Pathways Stem Cell Maintenance
Indications d'application FCM 1:20-100
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
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