TDP2 anticorps

N° du produit ABIN2704362

Cet anticorps Souris Monoclonal détecte spécifiquement TDP2 dans WB et FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour TDP2 anticorps (ABIN2704362)

Antigène: TDP2 (tyrosyl-DNA phosphodiesterase 2 (TDP2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TDP2 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Classe de qualité: GMP Grade

Clone: 42c

Détail du produit anti-TDP2 anticorps

Fonction: Anti-EAPII Unconjugated Antibody

Attributs du produit: EAPII (also called TTRAP, TDP2) originally was identified as an interacting partner of oncogene ETS1, a founding member of ets transcription factor, and the cytoplasmic domain of CD40, a member of the tumor necrosis factor (TNF) receptor family. EAPII significantly represses ETS1 transcriptional activity and the synergistic transactivation by ETS1 and AP-1 or by ETS1 and NFκB. EAPII/TTRAP also inhibits the transcriptional activation of NFB induced by CD40 or phorbol 12-myristate 13-acetate (PMA). Recently this protein was also proven to be the first 5'- tyrosyl-DNA phosphodiesterase. EAPII has been demonstrated to have promiscuous protein associations, broad responsiveness to various extracellular signals, and pleiotropic functions in the development of human diseases including cancer and neurodegenerative disease. Emerging data suggest that EAPII is a multi-functional protein: it repairs enzyme (topoisomerase)-mediated DNA damage by removing phosphotyrosine from DNA adducts, involves in multiple signal transduction pathways such as TNF-TNFR, TGFβ and MAPK, and responsive to immune defense including inflammatory response, viral infection and DNA toxins (chemo or radiation therapy). EAPII predominantly localizes to the nucleus, but based on pathological conditions it also localizes in both cytoplasm and nucleus.

Purification: Purified

Pureté: >95 %

Immunogène: Recombinant full length protein

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS pH 7.2, 0.1 % (w/v) BSA, 0.09 % (w/v) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Détails sur TDP2

Antigène: TDP2 (tyrosyl-DNA phosphodiesterase 2 (TDP2))

Autre désignation: EAPII

NCBI Accession: NM_016614

UniProt: O95551