CDKN2B anticorps

N° du produit ABIN271760

Détail du produit anti-CDKN2B anticorps

Antigène: CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDKN2B est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of p15 INK protein. (region surrounding Gly113)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen

Information d'application

Indications d'application: ELISA: 1/5000approx. 1/10000. Western Blot: 1/500approx. 1/1000. Immunohistochemistry: 1/50-1/200Immunofluorescence: 1/50approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur CDKN2B

Antigène: CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))

Autre désignation: CDKN2B / p15INK4b (CDKN2B Produits)

Synonymes: anticorps p14-INK4b, anticorps cdk4l, anticorps ink4b, anticorps mts2, anticorps p15, anticorps p15ink4b, anticorps tp15, anticorps CDK4I, anticorps INK4B, anticorps MTS2, anticorps P15, anticorps TP15, anticorps p15INK4b, anticorps AV083695, anticorps INK4b, anticorps p15(INK4b), anticorps CDKN2A, anticorps cyclin dependent kinase inhibitor 2B, anticorps Cyclin-dependent kinase 4 inhibitor B, anticorps cyclin-dependent kinase inhibitor 2B, anticorps cyclin-dependent kinase inhibitor 2B L homeolog, anticorps cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4), anticorps CDKN2B, anticorps cdn2b, anticorps cdkn2b, anticorps cdkn2b.L, anticorps Cdkn2b

Sujet: The normal progression of cells through the cell cycle is under the control of the cyclin dependent protein kinases Cdk4 and Cdk6 which are subject to inhibition by the mitotic inhibitory protein, p16. An isolated member of the p16 family has been designated p15. p15 expression is upregulated approximately 30-fold in TGFβ-treated human keratinocytes, suggesting that p15 may act as an effector of TGFβ-mediated cell cycle arrest. The gene encoding p15 has been mapped to chromosome 9p21 at a position adjacent to the p16 gene at a site of frequent chromosomal abnormality in human tumors. It has been suggested that p15 may function as an effector of TGFβ-mediated cell cycle arrest through inhibition of Cdk4 and Cdk6 kinases.Synonyms: Cyclin-dependent kinase 4 inhibitor B, MTS2, Multiple tumor suppressor 2, p14-INK4b, p14INK4b, p15-INK4b

Poids moléculaire: approx. 15 kDa

ID gène: 1030

NCBI Accession: NP_004927

UniProt: P42772

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases