PEA15 anticorps

N° du produit ABIN272058

Détail du produit anti-PEA15 anticorps

Antigène: PEA15 (phosphoprotein Enriched in Astrocytes 15 (PEA15))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PEA15 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of PEA-15 protein. (region surrounding Asp110)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Pureté: > 95 % pure by SDS-PAGE

Information d'application

Indications d'application: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200. IF: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS, pH 7.2., 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: DO NOT FREEZE!

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur PEA15

Antigène: PEA15 (phosphoprotein Enriched in Astrocytes 15 (PEA15))

Autre désignation: PEA15 (PEA15 Produits)

Synonymes: anticorps HMAT1, anticorps HUMMAT1H, anticorps MAT1, anticorps MAT1H, anticorps PEA-15, anticorps PED, anticorps Pea15a, anticorps PEA15, anticorps DKFZp459O1410, anticorps proliferation and apoptosis adaptor protein 15, anticorps phosphoprotein enriched in astrocytes 15, anticorps proliferation and apoptosis adaptor protein 15 L homeolog, anticorps Astrocytic phosphoprotein PEA-15, anticorps PEA15, anticorps Pea15, anticorps pea15.L, anticorps pea15

Sujet: PEA-15 (phosphoprotein enriched in astrocytes) exists in an non-phosphorylated form (N), and two phosphorylated forms, Pa and Pb. PEA-15 is an endogenous substrate for PKC, which mediates the transition from Pa to Pb. The level of PEA-15 phosphorylation changes upon depolymerization or stabilization of tubulins, indicating that PEA-15 co-localizes with microtubules. The first 80 amino acids of PEA-15 correspond to the death effector domain (DED), which is a domain found in proteins that regulate apoptotic signaling pathways. The DED domain is necessary for PEA-15 to block Ras suppression. Although PEA-15 is predominantly expressed in the central nervous system, low levels of PEA-15 are expressed in liver and kidney, and higher levels in muscle. PEA-15 is also referred to as PED, phosphoprotein enriched in diabetes, for its elevated expression in type 2 diabetic patients.Synonyms: Astrocytic phosphoprotein PEA-15, PED, Phosphoprotein enriched in diabetes

Poids moléculaire: approx. 36 kDa

ID gène: 8682

NCBI Accession: NP_003759

UniProt: Q15121