HNF1A anticorps

N° du produit ABIN272184

Détail du produit anti-HNF1A anticorps

Antigène: HNF1A (HNF1 Homeobox A (HNF1A))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HNF1A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of TCF-1 protein. (region surrounding Phe26)

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Pureté: > 95 % pure by SDS-PAGE

Information d'application

Indications d'application: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: DO NOT FREEZE!

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur HNF1A

Antigène: HNF1A (HNF1 Homeobox A (HNF1A))

Autre désignation: HNF1 alpha / TCF1 (HNF1A Produits)

Synonymes: anticorps HNF-1A, anticorps HNF1, anticorps IDDM20, anticorps LFB1, anticorps MODY3, anticorps TCF-1, anticorps TCF1, anticorps HNF-1a, anticorps AI323641, anticorps HNF1-alpha, anticorps HNF1[a], anticorps Hnf-1, anticorps Hnf1alpha, anticorps Tcf-1, anticorps Tcf1, anticorps HNF-1-alpha, anticorps HNF-1alpha, anticorps LF-B1, anticorps Lfb1, anticorps HNF-1, anticorps HNF1A, anticorps tcf1, anticorps FB1b, anticorps HNF1b, anticorps XLFB1b1, anticorps hnf1-B, anticorps lfb1b, anticorps mody3, anticorps tcf1-B, anticorps tcfb-A, anticorps HNF-1-alpha-A, anticorps HNF-1A-A, anticorps LFB1a1, anticorps TCF-1-A, anticorps XLFB1, anticorps XLFB1b, anticorps hnf1-a, anticorps hnf1a, anticorps hnf1a-a, anticorps hnf1a-b, anticorps hnf1a.L, anticorps tcf1-A, anticorps xx:af244934-22s, anticorps HNF1 homeobox A, anticorps HNF1 homeobox A L homeolog, anticorps HNF1 homeobox A S homeolog, anticorps HNF1 homeobox a, anticorps HNF1A, anticorps Hnf1a, anticorps hnf1a, anticorps hnf1a.L, anticorps hnf1a.S

Sujet: T-cell factor-1 (TCF-1) is a DNA-binding transcriptional activator that isessential for lymphoid cell development. The TCF family of transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, which mediates DNA binding. Several alternative splice variants of TCF-1 have been identified, including TCF-1A, which share a conserved amino terminus and differ in the carboxy terminal sequences. The Wnt mediated signaling pathway induces cytosolic β-catenin binding to TCF proteins within the nucleus, leading to the enhanced expression of the Wnt target genes. The β-catenin-TCF complexes are negatively regulated by the adenomatous polyposis coli (APC) tumor suppressor protein, which phosphorylates β-catenin and, in turn, increases the degradation of cytosolic β-catenin and inhibits the transcriptional activity of the TCF proteins. Mutations in the APC gene, which are commonly observed in colorectal carcinomas, disrupt this regulatory pathway and correlate with an accumulation of β-catenin and the increased activation of the TCF target genes.Synonyms: HNF1A, Hepatocyte nuclear factor 1-alpha, LF-B1, LFB1, Liver-specific transcription factor LF-B1, TCF-1, Transcription factor 1

Poids moléculaire: approx. 42 kDa

ID gène: 6927

NCBI Accession: NP_000536

UniProt: P20823

Pathways: Hormone Transport, Carbohydrate Homeostasis